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dc.contributor.authorDüğeroğlu, Harun
dc.contributor.authorÖztürk, Mustafa
dc.contributor.authorAtmaca, Murat
dc.contributor.authorSeven, İsmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:26Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:26Z
dc.date.issued2014en_US
dc.identifier.citationDüğeroğlu, H., Öztürk, M., Atmaca, M. ve Seven, İ. (2014). Mesterolone treatment of aging male syndrome improves lower urinary tract symptoms. Journal of the Pakistan Medical Association, 64(12), 1366-1369.en_US
dc.identifier.issn0030-9982
dc.identifier.urihttps://hdl.handle.net/20.500.12511/774
dc.description.abstractObjective: To investigate the effects of mesterolone on prostate in patients treated for aging male syndrome.Methods: The cross-sectional study was conducted from June to September, 2009, at endocrinology and metabolism department of Yuzuncu Yil University, Van, Turkey, and comprised patients with symptoms of aging male syndrome and/or low testosterone. They were given mesterolone 50mg/day per oral for two months. Aging Male Symptoms and International Prostate Symptom Score questionaires and prostate-related quality of life scores were completed and prostate ultrasonography (USG) was performed before and after the treatment. Total testosterone, free testosterone, gonadotropins, estradiol, prolactin, sex-hormone binding globulin, as well as total and free prostate-specific antigen were also studied.Results: Of the 34 patients in the study, 22(64.70%) had their prostate volume increased, while 12(35.29%) had it decreased. The change, however, was not statistically significant (p<0.098). Mesterolone significantly improved Aging Male Symptoms, International Prostate Symptom and prostate-related quality of life scores (p<0.001). These improvements though significant were independent of the changes in prostate volume. Total testosterone, sexhormone binding globulin andestradiol decreased, while free testosterone showed no change (p<0.002, p<0.001, p<0.024, p<0.337). The fraction of free testosterone increased (p<0.001), while total and free prostate-specific antigen did not change (p<0.368 and p<0.841).Conclusion: Mesterolone proved to be a safe alternative in the treatment of Aging Male Syndrome. It also improved lower urinary tract symptoms and prostate-related quality of life.en_US
dc.language.isoengen_US
dc.publisherPakistan Medical Associationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAndropauseen_US
dc.subjectMesteroloneen_US
dc.subjectProstateen_US
dc.titleMesterolone treatment of aging male syndrome improves lower urinary tract symptomsen_US
dc.typearticleen_US
dc.relation.journalJournal of the Pakistan Medical Associationen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-0947-9498en_US
dc.identifier.volume64en_US
dc.identifier.issue12en_US
dc.identifier.startpage1366en_US
dc.identifier.endpage1369en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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