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dc.contributor.authorAtaizi, Zeki Serdar
dc.contributor.authorÖzkoç, Mete
dc.contributor.authorKanbak, Güngör
dc.contributor.authorKarimkhani, Hadi
dc.contributor.authorBurukoğlu Dönmez, Dilek
dc.contributor.authorÜstünışık, Növber
dc.contributor.authorÖztürk, Buket
dc.date.accessioned2021-08-04T09:32:56Z
dc.date.available2021-08-04T09:32:56Z
dc.date.issued2021en_US
dc.identifier.citationAtaizi, Z. S., Özkoç, M., Kanbak, G., Karimkhani, H., Burukoğlu Dönmez, D., Üstünışık, N. ... Öztürk, B. (2021). Evaluation of the neuroprotective role of boric acid in preventing traumatic brain injury-mediated oxidative stress. Turkish Neurosurgery, 31(4), 493-499. https://dx.doi.org/10.5137/1019-5149.JTN.25692-18.4en_US
dc.identifier.issn1019-5149
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.25692-18.4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7669
dc.description.abstractAIM: To investigate the possible neuroprotective effect of boric acid (BA) by examining the changes in catalase (CAT) activity and levels of CAT and malondialdehyde (MDA) in brain tissues from rats with closed head trauma. MATERIAL and METHODS: The study consisted of three groups: control, traumatic brain injury (TBI) and TBI + BA. Animals in the control and TBI groups received saline, while animals in the TBI + BA group received BA through daily oral gavage, for 14 days prior to TBI was performed using the modified Marmarou impact acceleration model. After 24 hours, animals were euthanized, and brain tissue obtained to measure the levels of MDA and to assess the activity of CAT. RESULTS: MDA levels and CAT activity were significantly higher in the TBI group versus the control group. However, they were significantly lower in the TBI + BA group compared to TBI alone. Similarly, edema and necrotic neurons were observed in the TBI group, but not in the control or TBI + BA groups. CONCLUSION: Based on biochemical and histopathological evidence, we determined that TBI induced lipid peroxidation and oxidative stress were inhibited by pre-treatment with BA.en_US
dc.description.sponsorshipTurkish Neurosurgical Societyen_US
dc.language.isoengen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBoric Aciden_US
dc.subjectCatalaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.subjectTraumatic Brain Injuryen_US
dc.titleEvaluation of the neuroprotective role of boric acid in preventing traumatic brain injury-mediated oxidative stressen_US
dc.typearticleen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0002-4966-1745en_US
dc.identifier.volume31en_US
dc.identifier.issue4en_US
dc.identifier.startpage493en_US
dc.identifier.endpage499en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5137/1019-5149.JTN.25692-18.4en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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