dc.contributor.author | Çebi, Merve | |
dc.contributor.author | Durmuş, Hacer | |
dc.contributor.author | Yılmaz, Vuslat | |
dc.contributor.author | Yentür, Sibel Penbe | |
dc.contributor.author | Aysal, Fikret | |
dc.contributor.author | Oflazer, Zehra Piraye | |
dc.contributor.author | Parman, Yeşim Gülşen | |
dc.contributor.author | Deymeer, Feza | |
dc.contributor.author | Saruhan-Direskeneli, Güher | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:35:25Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:35:25Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Çebi, M., Durmuş, H., Yılmaz, V., Yentür S. P., Aysal, F., Oflazer, Z. P. ve Saruhan Direskeneli, G. (2019). Relation of HLA-DRB1 to IgG4 autoantibody and cytokine production in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG). Clinical and Experimental Immunology, 197(2), 214-221. https://dx.doi.org/10.1111/cei.13302 | en_US |
dc.identifier.issn | 0009-9104 | |
dc.identifier.issn | 1365-2249 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/764 | |
dc.identifier.uri | https://dx.doi.org/10.1111/cei.13302 | |
dc.description.abstract | A small subset of myasthenia gravis (MG) patients develop autoantibodies against muscle-specific kinase (MuSK), which are predominantly of the immunoglobulin (Ig)G4 isotype. MuSK-MG is strongly associated with HLA-DRB1*14, HLA-DRB1*16 and HLA-DQB1*05. In this study, the possible effects of these HLA associations on MuSK IgG autoantibody or cytokine production were investigated. Samples from 80 MG patients with MuSK antibodies were studied. The disease-associated HLA types were screened in the DNA samples. The IgG1, IgG2, IgG3 and IgG4 titres of the MuSK antibodies and the levels of interleukin (IL)-4, IL-6, IL-17A and IL-10 were measured in the sera. Comparisons were made among the groups with or without HLA-DRB1*14, HLA-DRB1*16 or HLA-DQB1*05. The IgG4 titres of the MuSK antibodies were higher than those of the IgG1, IgG2 and IgG3 isotypes among the whole group of patients. DRB1*14 (+) DRB1*16 (–) patients had higher levels of IgG4 antibodies than those of DRB1*14 (–) DRB1*16 (+) patients. DRB1*14 (+) DRB1*16 (+) patients also had higher levels of IgG4 antibodies than those of DRB1*14 (–) DRB1*16 (+) and DRB1*14 (–) DRB1*16 (–) patients. Higher IL-10 and lower IL-17A levels were measured in DRB1*14 (+) DRB1*16 (–) patients than in DRB1*14 (–) DRB1*16 (–) patients. The higher IgG4 titres of MuSK autoantibodies in patients carrying HLA-DRB1*14 than those in the other patients suggest a role for HLA in the production of the antibodies. The differences in IL-10 and IL-17A support the role of DRB1 in the etiopathogenesis of this autoimmune response. | en_US |
dc.description.sponsorship | Istanbul University | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | HLA | en_US |
dc.subject | IgG Isotype | en_US |
dc.subject | MuSK | en_US |
dc.subject | Myasthenia Gravis | en_US |
dc.title | Relation of HLA-DRB1 to IgG4 autoantibody and cytokine production in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG) | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Clinical and Experimental Immunology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 197 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 214 | en_US |
dc.identifier.endpage | 221 | en_US |
dc.relation.ec | info:eu-repo/grantAgreement/TUBITAK/SOBAG/116S317 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/cei.13302 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |