dc.contributor.author | Karaca, Oǧuz | |
dc.contributor.author | Omaygenç, Mehmet Onur | |
dc.contributor.author | Çakal, Beytullah | |
dc.contributor.author | Çakal, Sinem Deniz | |
dc.contributor.author | Güneş, Hacı Murat | |
dc.contributor.author | Barutçu, İrfan | |
dc.contributor.author | Boztosun, Bilal | |
dc.contributor.author | Kılıçaslan, Fethi | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:35:23Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:35:23Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Karaca, O., Omaygenç, M., Çakal, B., Çakal, S., Barutçu, İ., Boztosun, B. ... Kılıçaslan, F. (2016). Effect of QRS narrowing after cardiac resynchronization therapy on functional mitral regurgitation. American Journal of Cardiology, 117(3), 412-419. https://dx.doi.org/10.1016/j.amjcard.2015.11.010 | en_US |
dc.identifier.issn | 0002-9149 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/749 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.amjcard.2015.11.010 | |
dc.description.abstract | The determinants of improvement in functional mitral regurgitation (FMR) after cardiac resynchronization therapy (CRT) remain unclear. We evaluated the predictors of FMR improvement and hypothesized that CRT-induced change in QRS duration (?QRS) might have an impact on FMR response after CRT. One hundred ten CRT recipients were enrolled. CRT response (?15 reduction in left ventricular end-systolic volume) and FMR response (absolute reduction in FMR volume) were assessed with echocardiography before and 6 months after CRT. The study end points included all-cause death or hospitalization assessed in 12 ± 3 months (range 1 to 18). A total of 71 patients (65%) responded to CRT at 6 months. FMR response was observed in 49 (69%) of the CRT responders and 8 (20%) of the CRT nonresponders (p <0.001). Although the baseline QRS durations were similar, the paced QRS durations were shorter (p = 0.012) and the ?QRS values were greater (p = 0.003) in FMR responders compared with FMR nonresponders. There was a linear correlation between ?QRS and change in regurgitant volume (r = 0.49, p <0.001). At multivariate analysis, baseline tenting area (p = 0.012) and ?QRS (p = 0.028) independently predicted FMR response. A ?QRS ? 20 ms was related to CRT response, FMR improvement, and lower rates of death or hospitalization during follow-up (p values <0.05). In conclusion, QRS narrowing after CRT independently predicts FMR response. A ?QRS ?20 ms after CRT is associated with a favorable outcome in all clinical end points. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Inc. | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Mitral Valve Insufficiency | en_US |
dc.subject | Mitral Valve | en_US |
dc.subject | Ischemic Mitral | en_US |
dc.title | Effect of QRS narrowing after cardiac resynchronization therapy on functional mitral regurgitation in patients with systolic heart failure | en_US |
dc.type | article | en_US |
dc.relation.ispartof | American Journal of Cardiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4281-0867 | en_US |
dc.authorid | 0000-0003-2995-8792 | en_US |
dc.authorid | 0000-0003-0230-6575 | en_US |
dc.authorid | 0000-0003-2714-4584 | en_US |
dc.authorid | 0000-0001-5825-8627 | en_US |
dc.authorid | 0000-0002-4951-6716 | en_US |
dc.identifier.volume | 117 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 412 | en_US |
dc.identifier.endpage | 419 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.amjcard.2015.11.010 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q1 | en_US |