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dc.contributor.authorGüngel, H.
dc.contributor.authorAral, H.
dc.contributor.authorErdenen, F.
dc.contributor.authorGökçe, M.
dc.contributor.authorKaraman Erdur, Sevil
dc.date.accessioned2021-06-24T11:55:45Z
dc.date.available2021-06-24T11:55:45Z
dc.date.issued2020en_US
dc.identifier.citationGüngel, H., Aral, H., Erdenen, F., Gökçe, M. ve Karaman Erdur, S. (2020). Central macular thickness in diabetic macular edema. Acta Endocrinologica, 16(4), 417-425. https://dx.doi.org/10.4183/aeb.2020.417en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.urihttps://dx.doi.org/10.4183/aeb.2020.417
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7305
dc.description.abstractContext. Retinal microvascular dysfunction differs in macular edema lesions in the two eyes of the same patient with diabetic retinopathy. Objective. To evaluate the relationship between central macular thickness (CMT) and metabolic/systemic factors including anthropometric and laboratory findings, in patients with regressed diabetic retinopathy and a history of pars plana vitrectomy (PPV) combined with internal limiting membrane peeling in one eye. Subjects and Methods. Forty-two eyes with PPV and the same patients' fellow 42 eyes (without PPV) included this study. Fasting blood samples of these 42 diabetics were collected to study adiponectin levels and other routine parameters. Results. The average hemoglobinA lc value was 7.3 +/- 1.3%. CMT of the vitrectomized eyes were significantly correlated with atherogenic index of plasma, total cholesterol, low density lipoprotein cholesterol and uric acid (UA). On the other hand, CMT of the nonvitrectomized fellow eyes signifi cantly correlated with glucose levels and diabetes duration. Adiponectin, adiponectin/body mass index, adiponectin/fibrinogen were found significantly higher in the subgroup with CMT >= 300 mu m in the vitrectomized eyes (P<0.05). UA levels were higher in the subgroup with CMT >= 300 mu m in the fellow (nonvitrectomized) eyes (P<0.05). Conclusions. Although there was no relationship between CMT and hemoglobinA1c values, CMT seemed to be affected by atherogenicity, prooxidant chemical alterations in the course of inflammation, so determination of adiponectin and UA levels may be suggested before surgery to predict the atherosclerotic damage and the postoperative CMT value. Vitrectomy performed at the proper time may be helpful in metabolic remodeling process of the retinal tissue along with life style changes, well control of diabetes, and intraocular treatments.en_US
dc.language.isoengen_US
dc.publisherActa Endocrinologica Foundationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdiponectinen_US
dc.subjectUric Aciden_US
dc.subjectDiabetic Retinopathyen_US
dc.subjectMetabolismen_US
dc.subjectCentral Macular Thicknessen_US
dc.titleCentral macular thickness in diabetic macular edemaen_US
dc.typearticleen_US
dc.relation.journalActa Endocrinologicaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0001-9829-7268en_US
dc.identifier.volume16en_US
dc.identifier.issue4en_US
dc.identifier.startpage417en_US
dc.identifier.endpage425en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4183/aeb.2020.417en_US


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