Basit öğe kaydını göster

dc.contributor.authorKılıç, Fatih
dc.contributor.authorEskitaşçıoğlu, Teoman
dc.contributor.authorAydın, Ahmet
dc.contributor.authorÇakıcı, Özer Ural
dc.date.accessioned2021-05-03T11:23:07Z
dc.date.available2021-05-03T11:23:07Z
dc.date.issued2021en_US
dc.identifier.citationKılıç, F., Eskitaşçıoğlu, T., Aydın, A. ve Çakıcı, Ö. U. (2021). Ameliorating effects of beta-glucan on epigastric artery island flap ischemia-reperfusion injury. Journal of Surgical Research, 261, 282-292. https://dx.doi.org/10.1016/j.jss.2020.12.035en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.urihttps://dx.doi.org/10.1016/j.jss.2020.12.035
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6807
dc.description.abstractBackground: Ischemia-reperfusion injury has been one of the culprits of tissue injury and flap loss after island flap transpositions. Thus, significant research has been undertaken to study how to prevent or decrease the spread of ischemia-reperfusion injury. Preventive effects of beta-glucan on ischemia-reperfusion injury in the kidney, lung, and small intestine have previously been reported. In this study, we present the ameliorating effects of beta-glucan on ischemia-reperfusion injury using the epigastric artery island-flap in rats. Materials and methods: Thirty Wistar-Albino rats were equally divided into three groups: sham, experimental model, and treatment groups. In the sham group, an island flap was elevated and sutured back to the original position without any ischemia. In the experimental model group, the same-sized flap was elevated and sutured back with 8h of ischemia and consequent 12h of reperfusion. In the treatment group, 50 mg per kilogram beta-glucanwas administered to the rats using an orogastric tube for 10 d before the experiment. The same-sized flap is elevated and sutured back to its original position with 8 h of ischemia and 12 h of consequent reperfusion in the treatment group. Tissue biopsies were taken on the first day of the experimental surgery. Tissue neutrophil aggregation and vascular responses were evaluated by histological examinations. Tissue oxidant and antioxidant enzyme levels are evaluated biochemically after tissue homogenization. Topographic follow-up and evaluation of the flaps were maintained, and photographs were taken on the first and seventh day of the experimental surgery. Results: Topographic flap survival was significantly better in the beta-glucan administered group. The neutrophil number, malondialdehyde, and myeloperoxidase levels were significantly lower while glutathione peroxidase and superoxide dismutase levels were significantly higher in the beta-glucan administered group respective to the experimental model group. Conclusions: Based on the results of our study, we can conclude that beta-glucan is protective against ischemia-reperfusion injury. Our study presents the first experimental evidence of such an effect on skin island flaps.en_US
dc.description.sponsorshipErciyes Universityen_US
dc.language.isoengen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectRectus Abdominis Flapen_US
dc.subjectBeta-Glucanen_US
dc.titleAmeliorating effects of beta-glucan on epigastric artery island flap ischemia-reperfusion injuryen_US
dc.title.alternativeAmeliorating effects of β-glucan on epigastric artery island flap ischemia-reperfusion injuryen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalıen_US
dc.identifier.volume261en_US
dc.identifier.startpage282en_US
dc.identifier.endpage292en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jss.2020.12.035en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ1en_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster