dc.contributor.author | Elibol, Birsen | |
dc.contributor.author | Şahbaz, Çiğdem | |
dc.contributor.author | Eyüboğlu, Siğnem | |
dc.contributor.author | Çevreli, Burcu | |
dc.contributor.author | Kılıç, Ülkan | |
dc.contributor.author | Kılıç, Ertuğrul | |
dc.date.accessioned | 2021-05-03T10:30:42Z | |
dc.date.available | 2021-05-03T10:30:42Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Elibol, B., Şahbaz, Ç., Eyüboğlu, S., Çevreli, B., Kılıç, Ü. ve Kılıç, E. (2020). Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. Psychiatry and Behavioral Sciences, 10(3), 125-133. https://dx.doi.org/10.5455/PBS.20200604064021 | en_US |
dc.identifier.issn | 2636-834X | |
dc.identifier.uri | https://dx.doi.org/10.5455/PBS.20200604064021 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6804 | |
dc.description.abstract | Objective: Herein, we aimed to investigate the long-term effects of neonatal hypoxia and the potential protective role of melatonin and memantine on the learning and memory. Methods: Seven-day-old rat underwent right carotid ligation, followed by hypoxia. Rat received Melatonin (MLT) (4 mg/kg), Memantine (MEM) (20 mg/kg), and MLT+MEM combination after hypoxia. We tested these rats for anxiety by elevated O-maze and for spatial learning and memory by Morris water maze (MWM) at postnatal day 45. Results: Hypoxia increased the level of anxiety compared to the control group (p=0.05) while treatment of MLT, MEM, and MLT+MEM ameliorated this effect. In addition, hypoxia produced significant decrease in spatial learning of the rats on the fourth day of training (P=0.05) and the percent time spent in the platform quadrant and the entrance frequencies to the platform quadrant compared to the control group (P=0.049 and P=0.023). Treatment of MLT, MEM, and MLT+MEM after hypoxia improved the performance of the rats at the third (P=0.686, P=0.876, P=0.977, respectively) and fourth day (P=0.738, P=0.553, P=0.789, respectively) of MWM training. The decrease in the percent time spent was ameliorated by the treatment of MLT (P=0.239), MEM (P=0.289), and MLT+MEM (P=0.567) compared to the control group. In addition, MLT treatment significantly increased the entrance frequency to the platform quadrant compared to the hypoxia group (P=0.020). Conclusion: Our data suggested that the MLT was more effective in the release of memory deficits from hypoxia-related damage. MLT might have a therapeutic value in improving hypoxic damage in the developing brain. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Yerküre Tanıtım ve Yayıncılık Hizmetleri A.Ş. | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Neonatal Hypoxia | en_US |
dc.subject | Learning and Memory | en_US |
dc.subject | Melatonin | en_US |
dc.subject | Memantine | en_US |
dc.subject | Morris Water Maze | en_US |
dc.title | Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Psychiatry and Behavioral Sciences | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6494-8923 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 125 | en_US |
dc.identifier.endpage | 133 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.5455/PBS.20200604064021 | en_US |