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dc.contributor.authorKayalar, Emre
dc.contributor.authorTaş Deynek, Gül
dc.contributor.authorTok, Olgu Enis
dc.contributor.authorKüçük, Sevim
dc.date.accessioned2021-04-09T07:35:21Z
dc.date.available2021-04-09T07:35:21Z
dc.date.issued2021en_US
dc.identifier.citationKayalar, E., Taş Deynek, G., Tok, O.E. ve Küçük, S. (2021). Effect of salvianolic acid B on new bone formation in the orthopedically expanded suture: A histological and immunohistochemical study. Angle Orthodontist, 91(2), 248-254. https://dx.doi.org/10.2319/042620-360.1en_US
dc.identifier.issn0003-3219
dc.identifier.issn1945-7103
dc.identifier.urihttps://dx.doi.org/10.2319/042620-360.1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6716
dc.description.abstractObjectives: To determine the effects of Salvianolic acid B (Sal B) on new bone formation in the orthopedically expanded premaxillary sutures in rats.Materials and Methods: The sample consisting of Sprague Dawley rats (male, n = 14) was split in half by random selection: the experiment group (Sal B) and the control group. The premaxillary suture of each rat was expanded by bonding an open-loop spring to two maxillary incisors, each end to one tooth. A 5-day expansion period followed by a 12-day retention period was conducted. The 17-day intraperitoneal administration of Sal B was performed daily for the experiment group at a dose of 40 mg/kilo. The trial was completed after sacrificing the rats and dissection of the premaxillae for histological analysis. The amount of new bone, quantity of capillaries and intensity of inflammatory cells were histomorphometrically determined while the quantities of osteoblasts and osteoclasts were determined immunohistochemically.Results: The Sal B group was significantly different from the control group and had greater quantities of new bone, capillaries, inflammatory cells, osteoblasts, and osteoclasts.Conclusions: Salvianolic acid B displays a positive effect during premaxillary expansion with a greater number of capillaries potentially in association with higher bone formation and improved angiogenesis in rats.en_US
dc.description.sponsorshipScientific Research Projects Commission (BAP) of Anadolu University (Eskisehir, Turkey)en_US
dc.language.isoengen_US
dc.publisherE H Angle Education Research Foundation, Inc.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSalvianolic Acid Ben_US
dc.subjectBone Formationen_US
dc.subjectRapid Maxillary Expansionen_US
dc.titleEffect of salvianolic acid B on new bone formation in the orthopedically expanded suture: A histological and immunohistochemical studyen_US
dc.typearticleen_US
dc.relation.ispartofAngle Orthodontisten_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-4899-9146en_US
dc.identifier.volume91en_US
dc.identifier.issue2en_US
dc.identifier.startpage248en_US
dc.identifier.endpage254en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2319/042620-360.1en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ1en_US


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