dc.contributor.author | Şahinli, Hayriye | |
dc.contributor.author | Akyürek, Nalan | |
dc.contributor.author | Yılmaz, Mukaddes | |
dc.contributor.author | Kandemir, Olcay | |
dc.contributor.author | Ocak Duran, Ayşe | |
dc.contributor.author | Kulaçoğlu, Sezer | |
dc.contributor.author | Uçar, Gökhan | |
dc.contributor.author | Acar, Elif | |
dc.contributor.author | Özet, Ahmet | |
dc.contributor.author | Gümüş, Mahmut | |
dc.contributor.author | Çakmak Öksüzoğlu, Ömür Berna | |
dc.contributor.author | Yıldırım Özdemir, Nuriye | |
dc.date.accessioned | 2021-04-05T12:59:07Z | |
dc.date.available | 2021-04-05T12:59:07Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Şahinli, H., Akyürek, N., Yılmaz, M., Kandemir, O., Ocak Duran, A., Kulaçoğlu, S. ... Yıldırım Özdemir, N. (2021). PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma. Indian Journal of Cancer, 58(4), 561-566. https://dx.doi.org/10.4103/ijc.IJC_459_19 | en_US |
dc.identifier.issn | 0019-509X | |
dc.identifier.issn | 1998-4774 | |
dc.identifier.uri | https://dx.doi.org/10.4103/ijc.IJC_459_19 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6696 | |
dc.description.abstract | Background: Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients.Methods: Seventy patients diagnosed with non-metastatic NPC were included in the study. PD-L1 expression on immune cells was analyzed by immunohistochemical method. Patients were categorized into two groups according to the PD-L1 expression level in TIICs (level of PD-L1 staining ≥5% positive vs <5% negative).Results: Median follow-up period was 34 months (range = 1 - 188). 1 and 2 years survival rate were found as 75% and 63% in PD-L1 negative TIICs group (47%), and 85% and 83% in PD-L1 positive TIICs group (53%), respectively. PD-L1 positivity in immune cells (ICs) was detected in 53% of the patients. The survival rate was found better in the PD- L1 positive group compared to the negative group (P = 0.049).Discussion: In conclusion, the survival rate was found significantly better in the PD-L1 positive TIICs group, compared to the negative group. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Indian Cancer Society | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Nasopharyngeal Carcinoma | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Programmed Death Ligand-1 | en_US |
dc.title | PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Indian Journal of Cancer | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 561 | en_US |
dc.identifier.endpage | 566 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4103/ijc.IJC_459_19 | en_US |
dc.identifier.scopusquality | Q3 | en_US |