Comparison of the rates for reaching the blastocyst stage between normal and abnormal pronucleus embryos monitorized by time-lapse system in IVF patients
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CitationUzun, K. N., Cıncık, M., Selam, B., Takmaz, Ö. ve Uyar, E. (2020). Comparison of the rates for reaching the blastocyst stage between normal and abnormal pronucleus embryos monitorized by time-lapse system in IVF patients. Journal of the Turkish German Gynecological Association. https://dx.doi.org/10.4274/jtgga.galenos.2020.2020.0033
Objective: To compare the rates of blastocyst stage development between the embryos fertilizing after one (MPN) or more than two pronucleus (3PN, 4PN - MultiPN) with those after two pronucleus (2PN) in the same patients. The embryos were observed by the time-lapse system.Material and methods: As a total of 140 patients's embryos who had both abnormal PN (MPN, 3PN or 4PN) and normal fertilized (2PN) embryos after fertilization were followed with time-lapse system following ICSI procedure. The ratios for reaching the blastocyst stage were compared between normal and abnormally fertilized embryos.Results: 1820 oocytes were collected from 140 patients and 1280 (70.3%) of them were fertilized. MPN, 2 PN and 3PN, 4PN (MultiPN) ratios of the embryos in the pronuclear stage were 11.4%, 83.13% and 5.47%, respectively. The rates of reaching the blastocyst stage among these embryos were 17.1%, 60.8% and 42.8% for MPN, 2 PN and MultiPN, respectively. Rate of blastocyst development was significantly higher following 2PN compared to those after MPN and MultiPN (p<0,05). Embryos developing after MultiPN had significantly higher rates of reaching the blastocyst stage compared to those after the MPN (p<0.01).Conclusion: The majority of abnormally pronucleated embryos arrest without reaching the blastocyst stage. MultiPN embryos have higher ratios of blastocyst development than MPN embryos.
SourceJournal of the Turkish German Gynecological Association