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dc.contributor.authorÖztaş, Didem Melis
dc.contributor.authorMeriç, Mert
dc.contributor.authorBeyaz, Metin Onur
dc.contributor.authorÖnalan, Mehmet Akif
dc.contributor.authorSönmez, Kıvılcım
dc.contributor.authorÖter, Kerem
dc.contributor.authorZiyade, Sedat
dc.contributor.authorÖmer, Beyhan
dc.contributor.authorAlpagut, Ufuk
dc.contributor.authorUğurlucan, Murat
dc.date.accessioned2021-04-05T06:26:04Z
dc.date.available2021-04-05T06:26:04Z
dc.date.issued2020en_US
dc.identifier.citationÖztaş, D. M., Meriç, M., Beyaz, M. O., Önalan, M. A., Sönmez, K., Öter, K. ... Uğurlucan, M. (2020). Cardioprotective effects of erythropoietin in diabetic rats determined by CD34 and vascular endothelial growth factor levels. Archives of Medical Science - Atherosclerotic Diseases, 5, e1-e12. https://dx.doi.org/10.5114/amsad.2020.92346en_US
dc.identifier.issn2451-0629
dc.identifier.urihttps://dx.doi.org/10.5114/amsad.2020.92346
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6683
dc.description.abstractIntroduction: In this study, the effects of diabetes mellitus on the cardiovascular system were investigated by assessing the stem cell levels in serum and heart and compared with the normal population. Additionally, efficacy of erythropoietin, which is known to increase stem cells, was studied in diabetic rats.Material and methods: Twenty-five male Sprague Dawley rats were divided into three groups as a control group (group 1), diabetic group (group 2) and erythropoietin induced diabetic group (group 3). A diabetes model was created with streptozocin. In group 3 rats received 3000 U/kg of erythropoietin. At the end of 1 month blood reticulocyte levels, degree of tissue fibrosis and immunohistochemical assessment of reliable stem cell markers, CD34 and vascular endothelial growth factor (VEGF), were analyzed.Results: The increase in the blood glucose levels resulted in a significant decrease in reticulocyte levels in group 2. The increase in blood glucose levels resulted in a statistically significant increase in tissue level of fibrosis, CD34 and VEGF. When the rats in groups 1 and 2 were compared, the fibrosis, CD34 and VEGF levels were found to increase significantly. When group 2 and group 3 were compared, the amount of fibrosis was lower and the levels of CD34 and VEGF were significantly higher in group 3 than group 2.Conclusions: The results of our study indicated that the amount of CD34 and VEGF which function in cellular protection and tissue regeneration may be enhanced with safely applicable erythropoietin leading to increase in reticulocyte levels in serum, and CD34 and VEGF levels in right atrium, right ventricle, left atrium, and left ventricle as a protective mechanism in diabetic rats.en_US
dc.language.isoengen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectCardioprotective Effect Mechanismsen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectErythropoietinen_US
dc.titleCardioprotective effects of erythropoietin in diabetic rats determined by CD34 and vascular endothelial growth factor levelsen_US
dc.typearticleen_US
dc.relation.journalArchives of Medical Science - Atherosclerotic Diseasesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalıen_US
dc.authorid0000-0001-9338-8152en_US
dc.authorid0000-0001-6643-9364en_US
dc.identifier.volume5en_US
dc.identifier.startpagee1en_US
dc.identifier.endpagee12en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5114/amsad.2020.92346en_US


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