dc.contributor.author | Çubuk, Seçil | |
dc.contributor.author | Uçkan, Sina | |
dc.contributor.author | Özdemir, Handan | |
dc.contributor.author | Taşlıca, Zeynep Firdevs | |
dc.contributor.author | Bacanlı, Didem | |
dc.date.accessioned | 2021-04-01T08:37:16Z | |
dc.date.available | 2021-04-01T08:37:16Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Çubuk, S., Uçkan, S., Özdemir, H., Taşlıca, Z. F. ve Bacanlı, D. (2020). The efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide-induced squamous cell carcinoma of the tongue in rats. Journal of Oral and Maxillofacial Pathology, 24(2). https://dx.doi.org/10.4103/jomfp.JOMFP_88_18 | en_US |
dc.identifier.issn | 0973-029X | |
dc.identifier.issn | 1998-393X | |
dc.identifier.uri | https://dx.doi.org/10.4103/jomfp.JOMFP_88_18 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6671 | |
dc.description.abstract | Aims: The aim of this study to investigate the efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinogenesis of the tongue in rats.Subjects and methods: The sample was composed of 27 male Sprague Dawley rats that received 50 ppm 4NQO for 20 weeks in drinking water. Group 1 (n = 9) was treated with 50 mg/kg/day propranolol for 20 weeks, Group 2 (n = 9), after carcinogenesis inducement for 20 weeks, received propranolol (50 mg/kg/day) for 2 weeks and Group 3 (n = 9) received no treatment. At the end of the experimental stage, the tongue specimens were evaluated under a light microscope and categorized as low- or high-risk lesions according to a binary system.Statistical analysis used: The statistical comparison was performed with a likelihood ratio test.Results: Histopathological analysis revealed the risk of malignant transformation rates as 33.3% in Group 1, 55.5% in Group 2 and 77.8% in Group 3; however, the difference between the groups was not statistically significant (P > 0.05).Conclusion: The results of the study suggest that propranolol has a tendency to preventive effect against carcinogenesis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Medknow Publications Ltd. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | 4-Nitroquinoline 1-Oxide | en_US |
dc.subject | Carcinogenesis | en_US |
dc.subject | Chemoprevention | en_US |
dc.subject | Propranolol | en_US |
dc.title | The efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide-induced squamous cell carcinoma of the tongue in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Oral and Maxillofacial Pathology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-1077-7342 | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 2 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4103/jomfp.JOMFP_88_18 | en_US |