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dc.contributor.authorÇubuk, Seçil
dc.contributor.authorUçkan, Sina
dc.contributor.authorÖzdemir, Handan
dc.contributor.authorTaşlıca, Zeynep Firdevs
dc.contributor.authorBacanlı, Didem
dc.date.accessioned2021-04-01T08:37:16Z
dc.date.available2021-04-01T08:37:16Z
dc.date.issued2020en_US
dc.identifier.citationÇubuk, S., Uçkan, S., Özdemir, H., Taşlıca, Z. F. ve Bacanlı, D. (2020). The efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide-induced squamous cell carcinoma of the tongue in rats. Journal of Oral and Maxillofacial Pathology, 24(2). https://dx.doi.org/10.4103/jomfp.JOMFP_88_18en_US
dc.identifier.issn0973-029X
dc.identifier.issn1998-393X
dc.identifier.urihttps://dx.doi.org/10.4103/jomfp.JOMFP_88_18
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6671
dc.description.abstractAims: The aim of this study to investigate the efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinogenesis of the tongue in rats.Subjects and methods: The sample was composed of 27 male Sprague Dawley rats that received 50 ppm 4NQO for 20 weeks in drinking water. Group 1 (n = 9) was treated with 50 mg/kg/day propranolol for 20 weeks, Group 2 (n = 9), after carcinogenesis inducement for 20 weeks, received propranolol (50 mg/kg/day) for 2 weeks and Group 3 (n = 9) received no treatment. At the end of the experimental stage, the tongue specimens were evaluated under a light microscope and categorized as low- or high-risk lesions according to a binary system.Statistical analysis used: The statistical comparison was performed with a likelihood ratio test.Results: Histopathological analysis revealed the risk of malignant transformation rates as 33.3% in Group 1, 55.5% in Group 2 and 77.8% in Group 3; however, the difference between the groups was not statistically significant (P > 0.05).Conclusion: The results of the study suggest that propranolol has a tendency to preventive effect against carcinogenesis.en_US
dc.language.isoengen_US
dc.publisherMedknow Publications Ltd.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject4-Nitroquinoline 1-Oxideen_US
dc.subjectCarcinogenesisen_US
dc.subjectChemopreventionen_US
dc.subjectPropranololen_US
dc.titleThe efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide-induced squamous cell carcinoma of the tongue in ratsen_US
dc.typearticleen_US
dc.relation.journalJournal of Oral and Maxillofacial Pathologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.authorid0000-0003-1077-7342en_US
dc.identifier.volume24en_US
dc.identifier.issue2en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4103/jomfp.JOMFP_88_18en_US


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