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dc.contributor.authorAtay, Enver
dc.contributor.authorKılınç, Suna
dc.contributor.authorÜlfer, Gözde
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorTuran, Murat
dc.contributor.authorCeran, Ömer
dc.contributor.authorAtay, Zeynep
dc.date.accessioned2021-04-01T05:48:35Z
dc.date.available2021-04-01T05:48:35Z
dc.date.issued2021en_US
dc.identifier.citationAtay, E., Kılınç, S., Ülfer, G., Yiğitbaşı, T., Çakıcı, Ç., Turan, M. ... Atay, Z. (2021). The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty. Journal of Pediatric Endocrinology and Metabolism, 34(3), 325-332. https://dx.doi.org/10.1515/jpem-2020-0331en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.urihttps://dx.doi.org/10.1515/jpem-2020-0331
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6662
dc.description.abstractBackground: There is no data regarding the interrelationships of circulating Makorin Ring Finger Protein-3 (MKRN3), Kisspeptin (KISS1), and Neurokinin B (NKB) concentrations during minipuberty in humans.Objective: To determine temporal changes in circulating concentrations of MKRN3, KISS1, NKB, and gonadotropins and investigate interrelationships between them in healthy full-term (FT) and preterm (PT) infants during minipuberty period.Methods: A prospective study of 6-month follow-up performed. Eighty-seven healthy newborns, 48 FT (19 boys/29 girls), and 39 PT (21 boys/18 girls) (gestational age 31-37 weeks), were included. Blood samples were taken at 7 days (D7), 2 months (M2), and 6 months (M6) of age. Serum MKRN3, KISS1, NKB, LH, FSH, total testosterone (TT), and estradiol (E2) concentrations were measured.Results: Seventy infants completed the study. MKRN3, KISS1, and NKB concentrations were similar in FT girls and boys. PT boys and girls also had similar concentrations of MKRN3, KISS1, and NKB. FT babies had significantly higher NKB concentrations than PT babies at D7, M2, and M6. MKRN3 and KISS1 concentrations do not differ between FT and PT babies. A strong positive correlation was found between MKRN3 and KISS1 at each time point and in all groups. FSH, LH, TT/E2 concentrations decrease while those of MKRN3 and KISS1 have a trend to increase toward the end of minipuberty. No correlation was detected between gonadotropins and MKRN3, KISS1, NKB concentrations.Conclusion: Strong positive correlation demonstrated between KISS1 and MKRN3 suggests that interrelationship between molecules controlling minipuberty is not similar to those at puberty.en_US
dc.description.sponsorshipIstanbul Medipol University Scientific Research Support programen_US
dc.language.isoengen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKisspeptin (KISS1)en_US
dc.subjectMakorin Ring Finger Protein-3 (MKRN3)en_US
dc.subjectMinipubertyen_US
dc.subjectNeurokinin B (NKB)en_US
dc.titleThe role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipubertyen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolismen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0003-2350-6381en_US
dc.authorid0000-0002-0675-1839en_US
dc.authorid0000-0002-8662-5284en_US
dc.authorid0000-0002-8968-4079en_US
dc.authorid0000-0002-1044-6888en_US
dc.identifier.volume34en_US
dc.identifier.issue3en_US
dc.identifier.startpage325en_US
dc.identifier.endpage332en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1515/jpem-2020-0331en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ3en_US


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