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The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty

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info:eu-repo/semantics/closedAccess

Date

2021

Author

Atay, Enver
Kılınç, Suna
Ülfer, Gözde
Yiğitbaşı, Türkan
Çakıcı, Çağrı
Turan, Murat
Ceran, Ömer
Atay, Zeynep

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Citation

Atay, E., Kılınç, S., Ülfer, G., Yiğitbaşı, T., Çakıcı, Ç., Turan, M. ... Atay, Z. (2021). The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty. Journal of Pediatric Endocrinology and Metabolism, 34(3), 325-332. https://dx.doi.org/10.1515/jpem-2020-0331

Abstract

Background: There is no data regarding the interrelationships of circulating Makorin Ring Finger Protein-3 (MKRN3), Kisspeptin (KISS1), and Neurokinin B (NKB) concentrations during minipuberty in humans.Objective: To determine temporal changes in circulating concentrations of MKRN3, KISS1, NKB, and gonadotropins and investigate interrelationships between them in healthy full-term (FT) and preterm (PT) infants during minipuberty period.Methods: A prospective study of 6-month follow-up performed. Eighty-seven healthy newborns, 48 FT (19 boys/29 girls), and 39 PT (21 boys/18 girls) (gestational age 31-37 weeks), were included. Blood samples were taken at 7 days (D7), 2 months (M2), and 6 months (M6) of age. Serum MKRN3, KISS1, NKB, LH, FSH, total testosterone (TT), and estradiol (E2) concentrations were measured.Results: Seventy infants completed the study. MKRN3, KISS1, and NKB concentrations were similar in FT girls and boys. PT boys and girls also had similar concentrations of MKRN3, KISS1, and NKB. FT babies had significantly higher NKB concentrations than PT babies at D7, M2, and M6. MKRN3 and KISS1 concentrations do not differ between FT and PT babies. A strong positive correlation was found between MKRN3 and KISS1 at each time point and in all groups. FSH, LH, TT/E2 concentrations decrease while those of MKRN3 and KISS1 have a trend to increase toward the end of minipuberty. No correlation was detected between gonadotropins and MKRN3, KISS1, NKB concentrations.Conclusion: Strong positive correlation demonstrated between KISS1 and MKRN3 suggests that interrelationship between molecules controlling minipuberty is not similar to those at puberty.

WoS Q Kategorisi

Q3

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q3

Source

Journal of Pediatric Endocrinology and Metabolism

Volume

34

Issue

3

URI

https://dx.doi.org/10.1515/jpem-2020-0331
https://hdl.handle.net/20.500.12511/6662

Collections

  • Makale Koleksiyonu [3441]
  • PubMed İndeksli Yayınlar Koleksiyonu [3748]
  • Scopus İndeksli Yayınlar Koleksiyonu [5788]
  • WoS İndeksli Yayınlar Koleksiyonu [5966]



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