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dc.contributor.authorHeydari, Hajar
dc.contributor.authorKonuklugil, Belma
dc.contributor.authorGiray, Betül
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorGüzel, Mustafa
dc.date.accessioned2021-02-19T11:42:19Z
dc.date.available2021-02-19T11:42:19Z
dc.date.issued2020en_US
dc.identifier.citationHeydari, H., Konuklugil, B., Giray, B., Karadağ, A. E. ve Güzel, M. (2020). Identification and in vitro bioactivity screening of some marine-derived fungi from Turkish coastlines. Cahiers de Biologie Marine, 61(5), 437-446. https://dx.doi.org/10.21411/CBM.A.A3EE9FBen_US
dc.identifier.issn0007-9723
dc.identifier.issn2262-3094
dc.identifier.urihttps://dx.doi.org/10.21411/CBM.A.A3EE9FB
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6570
dc.description.abstractThe marine environment represents a great variety of conditions of pressure, temperature, salinity, and light depending on depth, latitude and interactions with the continental shelf. These extreme and variable conditions enforce marine-derived microbial communities to produce a variety of structurally complex secondary metabolites which may have considerable pharmaceutical potential. In this study four marine-derived fungi were successfully isolated and identified from marine invertebrates (Axinella cannabina, Aplysina aerophoba, Axinella verrucosa, Dendrectilla tremitersis) and investigated for their antioxidant, cytotoxic, antifungal and antimicrobial activities. Three marine fungi strains - Aspergillus sp., Trichoderma sp. and Rhizopus oryzae - were isolated and identified genotypically. Aspergillus sp. had the highest antioxidant activity, and together with Rhizopus oryzae also showed significant cytotoxic activity against HCT-116 cell line. Moreover, among the tested marine-derived fungi extracts Aspergillus sp. was exhibited the highest antifungal activity against Botrytis cinerea.en_US
dc.description.abstractRésumé : Identification et criblage in vitro du potentiel thérapeutique de certains champignongs d’origine marine des côtes turques. L’environnement marin représente une grande variété de conditions de pression, température, salinité et lumière selon la profondeur, la latitude et les interactions avec le plateau continental. Ces conditions extrêmes et variables ont conduit les communautés microbiennes marines à produire une profusion de métabolites secondaires structuralement complexes pouvant avoir un potential pharmaceutique considérable. Dans cette étude, quatre champignons ont été isolés et identifiés à partir d’invertébrés marins (Axinella cannabina, Aplysina aerophoba, Axinella verrucosa, Dendrectilla tremitersis) pour étudier leurs propriétés antioxydantes, cytotoxiques, antifongiques et antimicrobiennes. En particulier, des lignées associées à Aspergillus sp., Trichoderma sp. et Rhizopus oryzae ont été isolées et caractérisées génétiquement. Alors qu’Aspergillus sp. possède la plus forte activité anti-oxydante, ce champignon et Rhizopus oryzae ont également un effet cytotoxique significatif sur la lignée cellulaire humaine HCT-116. De plus, parmi les différentes souches de champignon testées, Aspergillus sp. présente également les activités anti-fongiques les plus élevées contre Botrytis cinerea.en_US
dc.language.isoengen_US
dc.publisherCahiers de Biologie Marineen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectAntifungalen_US
dc.subjectAntimicrobial Activitiesen_US
dc.subjectCytotoxicityen_US
dc.subjectMarine Derived-Fungien_US
dc.titleIdentification and in vitro bioactivity screening of some marine-derived fungi from Turkish coastlinesen_US
dc.title.alternativeIdentification et criblage in vitro du potentiel thérapeutique de certains champignongs d’origine marine des côtes turquesen_US
dc.typearticleen_US
dc.relation.ispartofCahiers de Biologie Marineen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-1318-6476en_US
dc.authorid0000-0002-3412-0807en_US
dc.identifier.volume61en_US
dc.identifier.issue5en_US
dc.identifier.startpage437en_US
dc.identifier.endpage446en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/BMBF-114S916
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.21411/CBM.A.A3EE9FBen_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ4en_US


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