• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace@Medipol
  • Fakülteler
  • Mühendislik ve Doğa Bilimleri Fakültesi
  • Biomedical Engineering
  • Makale Koleksiyonu
  • View Item
  •   DSpace@Medipol
  • Fakülteler
  • Mühendislik ve Doğa Bilimleri Fakültesi
  • Biomedical Engineering
  • Makale Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions

Thumbnail

View/Open

Tam Metin / Full Text (1.999Mb)

Access

info:eu-repo/semantics/embargoedAccess

Date

2021

Author

Lashkarinia, S. Samaneh
Çoban, Gürsan
Köse, Banu
Salihoğlu, Ece
Pekkan, Kerem

Metadata

Show full item record

Citation

Lashkarinia, S. S., Çoban, G., Köse, B., Salihoğlu, E. ve Pekkan, K. (2021). Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions. Journal of Biomechanics, 117. https://dx.doi.org/10.1016/j.jbiomech.2021.110274

Abstract

Recent progress in vascular growth mechanics has involved the use of computational algorithms to address clinical problems with the use of three-dimensional patient specific geometries. The objective of this study is to establish a predictive computational model for the volumetric growth of pulmonary arterial (PA) tissue following complex cardiovascular patch reconstructive surgeries for congenital heart disease patients. For the first time in the literature, the growth mechanics and performance of artificial cardiovascular patches in contact with the growing PA tissue domain is established. An elastic-growing material model was developed in the open source FEBio software suite to first examine the surgical patch reconstruction process for an idealized main PA anatomy as a benchmark model and then for the patient-specific PA of a newborn. Following patch reconstruction, high levels of stress and strain are compensated by growth on the arterial tissue. As this growth progresses, the arterial tissue is predicted to stiffen to limit elastic deformations. We simulated this arterial growth up to the age of 18 years, when somatic growth plateaus. Our research findings show that the non-growing patch material remains in a low strain state throughout the simulation timeline, while experiencing high stress hot-spots. Arterial tissue growth along the surgical stitch lines is triggered mainly due to PA geometry and blood pressure, rather than due to material property differences in the artificial and native tissue. Thus, non-uniform growth patterns are observed along the arterial tissue proximal to the sutured boundaries. This computational approach is effective for the pre-surgical planning of complex patch surgeries to quantify the unbalanced growth of native arteries and artificial non-growing materials to develop optimal patch biomechanics for improved postoperative outcomes.

WoS Q Kategorisi

Q3

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q1

Source

Journal of Biomechanics

Volume

117

URI

https://dx.doi.org/10.1016/j.jbiomech.2021.110274
https://hdl.handle.net/20.500.12511/6552

Collections

  • Makale Koleksiyonu [69]
  • PubMed İndeksli Yayınlar Koleksiyonu [3758]
  • Scopus İndeksli Yayınlar Koleksiyonu [5797]
  • WoS İndeksli Yayınlar Koleksiyonu [5977]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Guide | Contact |

DSpace@Medipol

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValueScopus Q ValuePublisherAccess TypeThis CollectionBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValueScopus Q ValuePublisherAccess Type

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Guide || Library || İstanbul Medipol University || OAI-PMH ||

Kütüphane ve Dokümantasyon Daire Başkanlığı, İstabul, Turkey
If you find any errors in content, please contact: [email protected]

Creative Commons License
DSpace@Medipol by İstanbul Medipol University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Medipol:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.