dc.contributor.author | İnanç, Nevsun | |
dc.contributor.author | Mumcu, Gonca | |
dc.contributor.author | Can, Meryem | |
dc.contributor.author | Yay, Meral | |
dc.contributor.author | Silbereisen, Angelika | |
dc.contributor.author | Manoil, Daniel | |
dc.contributor.author | Direskeneli, Haner | |
dc.contributor.author | Bostancı, Nagihan | |
dc.date.accessioned | 2021-02-12T05:59:02Z | |
dc.date.available | 2021-02-12T05:59:02Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | İnanç, N., Mumcu, G., Can, M., Yay, M., Silbereisen, A., Manoil, D. ... Bostancı, N. (2021). Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis. Scientific Reports, 11(1). https://dx.doi.org/10.1038/s41598-021-82335-9 | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://dx.doi.org/10.1038/s41598-021-82335-9 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6551 | |
dc.description.abstract | The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis. | en_US |
dc.description.sponsorship | Marmara Üniversitesi ; Janggen-Pöhn-Stiftung ; Karolinska Institutet | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Rheumatoid | en_US |
dc.subject | Disease Activity | en_US |
dc.subject | Elevated Serum TREM-1 | en_US |
dc.title | Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-9927-3644 | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 1 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1038/s41598-021-82335-9 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |