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dc.contributor.authorİnanç, Nevsun
dc.contributor.authorMumcu, Gonca
dc.contributor.authorCan, Meryem
dc.contributor.authorYay, Meral
dc.contributor.authorSilbereisen, Angelika
dc.contributor.authorManoil, Daniel
dc.contributor.authorDireskeneli, Haner
dc.contributor.authorBostancı, Nagihan
dc.date.accessioned2021-02-12T05:59:02Z
dc.date.available2021-02-12T05:59:02Z
dc.date.issued2021en_US
dc.identifier.citationİnanç, N., Mumcu, G., Can, M., Yay, M., Silbereisen, A., Manoil, D. ... Bostancı, N. (2021). Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis. Scientific Reports, 11(1). https://dx.doi.org/10.1038/s41598-021-82335-9en_US
dc.identifier.issn2045-2322
dc.identifier.urihttps://dx.doi.org/10.1038/s41598-021-82335-9
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6551
dc.description.abstractThe triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis.en_US
dc.description.sponsorshipMarmara Üniversitesi ; Janggen-Pöhn-Stiftung ; Karolinska Instituteten_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectRheumatoiden_US
dc.subjectDisease Activityen_US
dc.subjectElevated Serum TREM-1en_US
dc.titleElevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritisen_US
dc.typearticleen_US
dc.relation.ispartofScientific Reportsen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-9927-3644en_US
dc.identifier.volume11en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1038/s41598-021-82335-9en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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