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dc.contributor.authorKaya, Yasin Emre
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorYaman, Onur
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorAteş, Özkan
dc.date.accessioned2021-02-05T12:45:03Z
dc.date.available2021-02-05T12:45:03Z
dc.date.issued2020en_US
dc.identifier.citationKaya, Y. E., Karaarslan, N., Yılmaz, İ., Yaşar Şirin, D., Yaman, O., Özbek, H. ... Ateş, Ö. (2020). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, 27(4), 1082-1087. https://doi.org/10.5455/annalsmedres.2019.11.780en_US
dc.identifier.issn2636-7688
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2019.11.780
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6533
dc.description.abstractAbstract Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix. Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05. Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05). Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.en_US
dc.language.isoengen_US
dc.publisherAnnals of Medical Research Publishing Incen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChondroadherin Geneen_US
dc.subjectCartilage Oligomeric Proteinen_US
dc.subjectInterleukin-1betaen_US
dc.subjectMatrix Metalloproteinaseen_US
dc.subjectPrimary Chondrocyte Cultureen_US
dc.subjectTigecyclineen_US
dc.titleInvestigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte culturesen_US
dc.typearticleen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-2003-6337en_US
dc.authorid0000-0002-8084-7855en_US
dc.identifier.volume27en_US
dc.identifier.issue4en_US
dc.identifier.startpage1082en_US
dc.identifier.endpage1087en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5455/annalsmedres.2019.11.780en_US


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