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dc.contributor.authorŞirin, Dursun Ali
dc.contributor.authorÖzçelik, Fatih
dc.contributor.authorErşahan, Şeyda
dc.contributor.authorPençe, Halime Hanım
dc.date.accessioned2021-01-27T10:35:20Z
dc.date.available2021-01-27T10:35:20Z
dc.date.issued2021en_US
dc.identifier.citationŞirin, D. A., Özçelik, F., Erşahan, Ş. ve Pençe, H. H. (2021). The importance of inflammatory biomarkers, IL-6 and PAPP-A, in the evaluation of asymptomatic apical periodontitis. Odontology, 109(1), 250-258. https://dx.doi.org/10.1007/s10266-020-00534-8en_US
dc.identifier.issn1618-1247
dc.identifier.issn1618-1255
dc.identifier.urihttps://dx.doi.org/10.1007/s10266-020-00534-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6414
dc.description.abstractTo examine the use of IL-6 and PAPP-A along with the new imaging for scoring methods to determine the severity of apical periodontitis (AP). The scoring of disease severity in 121 patients with AP, using dental radiographs, was based on "The Apical Periodontitis Grading Scale" (APGS), as those having 1 tooth with AP and severity of 3-4 were classified as grade 1 (mild); those having > 1 tooth and severity of 3-4 as grade 2 (moderate) and those with at least one tooth with a severity of 5 as grade 3 (severe). 45 systematically and orally healthy volunteers were selected as the control group (grade 0). Dental demographic data of all participants were recorded. Besides, venous blood samples were collected to study their complete blood count and levels of IL-6 and PAPP-A. Both NLR and PAPP-A levels of the grade 3 AP patients were found significantly higher than those of the control group and grade 1 and grade 2 AP patients (2.55 +/- 1.40 vs 1.98 +/- 1.05, 1.94 +/- 0.58 and 1.86 +/- 0.50; 0.606 +/- 0.211 vs 0.422 +/- 0.273, 0.447 +/- 0.224 and 0.436 +/- 0.242,p < 0.01, respectively). AP grades identified by the new scoring system were moderately correlated with IL-6 levels (Spearmanr = 0.4168,p < 0.001). The risk of patients with IL-6 levels above 12.5 pg/ml to develop AP (relative risk) was found to be 2.19 times higher than that in those with lower IL-6 levels (98% Cl 1.233-3.905,p < 0.0024). APGS classification suggested to determine AP severity was found to be significantly correlated with levels of inflammatory markers IL-6 and PAPP-A.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectApical Periodontitisen_US
dc.subjectIL-6en_US
dc.subjectPAPP-Aen_US
dc.titleThe importance of inflammatory biomarkers, IL-6 and PAPP-A, in the evaluation of asymptomatic apical periodontitisen_US
dc.typearticleen_US
dc.relation.journalOdontologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalıen_US
dc.authorid0000-0002-0354-5108en_US
dc.identifier.volume109en_US
dc.identifier.issue1en_US
dc.identifier.startpage250en_US
dc.identifier.endpage258en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10266-020-00534-8en_US


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