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dc.contributor.authorBener, Abdulbari
dc.contributor.authorÖzdenkaya, Yaşar
dc.contributor.authorAl-Hamaq, Abdulla O. A. A.
dc.contributor.authorBarışık, Cem Cahit
dc.contributor.authorÖztürk, Mustafa
dc.date.accessioned2021-01-27T07:32:27Z
dc.date.available2021-01-27T07:32:27Z
dc.date.issued2018en_US
dc.identifier.citationBener, A., Özdenkaya, Y., Al-Hamaq, A.O. A. A., Barışık, C. C. ve Öztürk, M. (2018). Low vitamin D deficiency associated with thyroid disease among type 2 diabetic mellitus patients. Journal of Clinical Medicine Research, 10(9), 707-714. https://dx.doi.org/10.14740/jocmr3507wen_US
dc.identifier.issn1918-3003
dc.identifier.issn1918-3011
dc.identifier.urihttps://dx.doi.org/10.14740/jocmr3507w
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6408
dc.description.abstractBackground: The aim of this study was to investigate the relationship between vitamin D deficiency and thyroid diseases among type 2 diabetes mellitus (T2DM) patients.Methods: This was a cohort case and control study, 546 T2DM patients and 546 control study participants were enrolled, aged between 25 and 65 years. The subjects were also investigated for fasting blood glucose levels (FBG), post prandial glucose (PPG,) glycosylated hemoglobin (HbA1c), thyroid stimulating hormone (TSH), T3, T4, and presence of other comorbid conditions. Thyroid fine needle aspiration biopsy was suggested to patients whose thyroid nodules were greater than 1.00 cm.Results: There were significant differences between T2DM patients and control subjects regarding BMI (kg/m2), physical activity, cigarette smoking, sheesha smoking, family history of diabetes, hypertension and family history of thyroid nodules. The clinical biochemistry values among T2DM for vitamin D, calcium, magnesium, potassium, phosphorous, fasting blood glucose, cholesterol, HbA1c, HLDL, LDL, triglyceride, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were lower than control subjects, but higher in creatinine, albumin, TSH, T3, and T4 which appeared statistically significant differences (P < 0.001). Also, the study revealed statistically significant differences between subjects vitamin D deficiency and with thyroid nodules for calcium, magnesium, phosphorous, HbA1c, high density lipoprotein (HDL), SBP and DBP, TSH, T3, and T4 among T2DM patients and control subjects (P < 0.001). Multivariable stepwise logistic regression analysis showed that TSH, HbA1c, vitamin D deficiency, SBP (mm Hg), BMI, family history of DM, serum calcium level and family history of thyroid were considered at higher risk as predictors of thyroid among T2DM patients.Conclusions: This study suggests that obesity, HbA1c, the environment, and genetic susceptibility among T2DM, may increase the risk of thyroid disease and cancer. Although evidence has shown that thyroid cancer incidence has been rising more rapidly over time than the occurrence of cancers of other sites, due to an increase of obesity, diabetes and lack of physical activity, this study lacks of direct evidence supporting this conclusion.en_US
dc.language.isoengen_US
dc.publisherElmer Pressen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectVitamin D Deficiencyen_US
dc.subjectThyroid Diseaseen_US
dc.subjectTSHen_US
dc.subjectHba1cen_US
dc.subjectT2DMen_US
dc.subjectPreventionen_US
dc.titleLow vitamin D deficiency associated with thyroid disease among type 2 diabetic mellitus patientsen_US
dc.typearticleen_US
dc.relation.journalJournal of Clinical Medicine Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-7902-5803en_US
dc.authorid0000-0003-3540-6492en_US
dc.identifier.volume10en_US
dc.identifier.issue9en_US
dc.identifier.startpage707en_US
dc.identifier.endpage714en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.14740/jocmr3507wen_US


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