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dc.contributor.authorGemici, Aliihsan
dc.contributor.authorBilgen, Hülya
dc.contributor.authorErdoğan, Cem
dc.contributor.authorKansu, Abdullah
dc.contributor.authorOlmuşçelik, Oktay
dc.contributor.authorBeköz, Hüseyin Saffet
dc.contributor.authorDinleyici, Rümeysa
dc.contributor.authorMert, Ali
dc.contributor.authorSevindik, Ömür Gökmen
dc.date.accessioned2021-01-14T07:16:53Z
dc.date.available2021-01-14T07:16:53Z
dc.date.issued2020en_US
dc.identifier.citationGemici, A., Bilgen, H., Erdoğan, C., Kansu, A., Olmuşçelik, O., Beköz, H. S. ... Sevindik, Ö. G. (2020). A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma. Turkish Journal of Medical Sciences, 50(8), 1781-1785. https://dx.doi.org/10.3906/sag-2009-77en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://dx.doi.org/10.3906/sag-2009-77
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6239
dc.description.abstractBackground/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. Health authority in Turkey has published a guideline to integrate this promising option in the treatment process of patients who are prone to high risk of developing severe COVID-19.Materials and Methods: Forty consecutive patients who had received CP at our center were included in the study. Demographics, COVID-19 specific parameters, biomarkers to detect the severity of COVID-19 infection and outcome variables were collected retrospectively. The correlation between outcome variables and the independent predictors of the outcome were reported.Results: Median age of the patients was 57.5 and 72.5% were male. At least one COVID-19 PCR test was confirmed to be positive in 75% of patients. Remaining 25% had a Chest-CT which was reported to be compatible with an ongoing COVID-19. All patients (100%) were classified as having severe COVID-19 infection. Over a half of the patients harbored an oxygen saturation of less than 90 despite of a continuous 5 L/min support of O-2. 82.5% of the patients had a need for mechanical ventilation and 45.5% had a need for invasive mechanical ventilation. Nine out of 10 patients who have received CP outside ICU have totally recovered from COVID-19 at a median of 9 days, and a half of the patients who needed invasive mechanical ventilation were successfully free of mechanical ventilation support and managed to recover from COVID-19.Conclusion: According to the results of this study, CP is an efficient conjunct to conventional therapy against COVID-19 with a favorable safety profile.en_US
dc.language.isoengen_US
dc.publisherTübitak Scientific & Technical Research Council Turkeyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectConvalescent Plasmaen_US
dc.subjectCOVID-19en_US
dc.subjectViral Infectionsen_US
dc.titleA single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasmaen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-3385-8359en_US
dc.authorid0000-0002-7424-8688en_US
dc.authorid0000-0002-5715-8138en_US
dc.authorid0000-0001-8902-5498en_US
dc.authorid0000-0002-9815-1848en_US
dc.authorid0000-0003-1237-8281en_US
dc.authorid0000-0001-8930-741Xen_US
dc.authorid0000-0001-8945-2385en_US
dc.authorid0000-0001-9636-4113en_US
dc.identifier.volume50en_US
dc.identifier.issue8en_US
dc.identifier.startpage1781en_US
dc.identifier.endpage1785en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3906/sag-2009-77en_US


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