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dc.contributor.authorŞahin, Zafer
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned2021-01-07T07:12:21Z
dc.date.available2021-01-07T07:12:21Z
dc.date.issued2020en_US
dc.identifier.citationŞahin, Z., Biltekin, S. N., Yurttaş, L. ve Demirayak, Ş. (2020). Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs. Turkish Journal of Chemistry, 44(6), 1733-1741. https://dx.doi.org/10.3906/kim-2008-8en_US
dc.identifier.issn1300-0527
dc.identifier.urihttps://dx.doi.org/10.3906/kim-2008-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6192
dc.description.abstractMarine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. Structures are elucidated by NMR (H-1, C-13) and HRMS spectrums. As an alkaloid derivative, antioxidant properties were evaluated with DPPH and FRAP assays and antimicrobial effect with microclilution method. Among the series, 3bc-3cf showed higher antioxidant activity than those having 3 or 4-pyridyl substituents. There is lesser activity for 2-pyridyl activity for 2-pyridyl containing group, which may be a result of intramolecular interactions. No activity was observed against gram-negative bacteria at 250 mu g/mL. 3ae and 3ce showed activity at 64 mu g/mL against S. aureus and 3ae showed activity at 16 pg/ml. against S. epidermidis gram-positive bacteria. Chloramphenicol showed activity against all microorganisms at 8-16 mu g/mL. Sixteen original dendrodoine analogs have been defined by close/higher activity compared to dendrodoine analogs and Trolox.en_US
dc.language.isoengen_US
dc.publisherScientific and Technical Research Council of Turkeyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectThiazoleen_US
dc.subjectDendrodoineen_US
dc.titleSynthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogsen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Chemistryen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-5976-676Xen_US
dc.authorid0000-0003-1896-2729en_US
dc.authorid0000-0002-0841-1299en_US
dc.identifier.volume44en_US
dc.identifier.issue6en_US
dc.identifier.startpage1733en_US
dc.identifier.endpage1741en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3906/kim-2008-8en_US


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