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dc.contributor.authorYıldırım, Süleyman
dc.contributor.authorShoskes, Daniel
dc.contributor.authorKulkarni, Sanjay
dc.contributor.authorLaguna, Pilar
dc.date.accessioned2020-12-03T07:52:33Z
dc.date.available2020-12-03T07:52:33Z
dc.date.issued2020en_US
dc.identifier.citationYıldırım, S., Shoskes, D., Kulkarni, S. ve Laguna, P. (2020). Urinary microbiome in uncomplicated and interstitial cystitis: Is there any similarity? World Journal of Urology, 38(11), 2721-2731. https://dx.doi.org/10.1007/s00345-020-03099-xen_US
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.urihttps://dx.doi.org/10.1007/s00345-020-03099-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6075
dc.description.abstractPurpose Acute/uncomplicated cystitis is the most common bacterial infection causing inflammation in the bladder tissues and predominantly diagnosed in women. Interstitial cystitis may too, cause inflammation in the bladder but its etiology has been elusive. Even though the site and symptoms of both diseases are largely shared, state of the urinary microbiome in these disorders have not been comparatively evaluated before. The purpose of this review is to assess and qualitatively compare structure and composition of the urinary microbiome in acute/uncomplicated cystitis and interstitial cystitis. Methods and results The available literature in MEDLINE are extensively searched using keywords and screened. Pertinent evidence is carefully assessed and synthesized. We included the original studies with a cohort of medically stable, non-pregnant women with otherwise functionally normal urinary tract and excluded the original articles if the infection in a patient's cohort is accompanied by urinary syndromes such as incontinence and overactive bladder syndrome. A total of six original papers reporting on the urinary microbiome in acute cystitis and nine papers on the interstitial cystitis met the selection criteria. Conclusion The evidence we have gleaned from the literature on the urinary microbiome associated with the acute and interstitial cystitis does not point to convergence of microbiome similarities between the two diseases. More studies with direct sampling of the bladder tissues besides sampling bladder surfaces are warranted for accurate comparison of microbiome similarity between the two conditions. The future research on interstitial cystitis microbiome should include stratified cohorts with prospective design.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectUtisen_US
dc.subjectCystitisen_US
dc.subjectUrinary Microbiomeen_US
dc.subject16S rRNAen_US
dc.subjectMetagenomicsen_US
dc.titleUrinary microbiome in uncomplicated and interstitial cystitis: Is there any similarity?en_US
dc.typearticleen_US
dc.relation.ispartofWorld Journal of Urologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-2752-1223en_US
dc.authorid0000-0003-0906-4417en_US
dc.identifier.volume38en_US
dc.identifier.issue11en_US
dc.identifier.startpage2721en_US
dc.identifier.endpage2731en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00345-020-03099-xen_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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