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dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorÇalışoğlu, Pervin
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2020-11-12T06:18:35Z
dc.date.available2020-11-12T06:18:35Z
dc.date.issued2020en_US
dc.identifier.citationHelvacı Yılmaz, N., Çalışoğlu, P., Güntekin, B. ve Hanoğlu, L. (2020). Correlation between alpha activity and neuropsychometric tests in Parkinson's disease. Neuroscience Letters, 738. https://dx.doi.org/10.1016/j.neulet.2020.135346en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.urihttps://dx.doi.org/10.1016/j.neulet.2020.135346
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6011
dc.description.abstractParkinson's disease (PD) is a neurodegenerative disease that leads to memory impairment and executive and visuospatial dysfunction as the disease progresses. Alpha activity on EEG has been related to cognition in previous studies. We aimed to investigate the correlation between alpha activity and neuropsychometric tests (NPTs) in PD patients. Fifty-five idiopathic PD patients and 20 healthy controls were included. The Standardized Mini-Mental Test (SMMT), Verbal Learning Memory Test (VLMT), Wechsler Memory Scale (WMS), Stroop Color-Word Test, Categorical Verbal Fluency Test (CVFT), Benton's Face Recognition Test (BFR), and Benton Line Judgment Orientation Test (BLOT) were administered to all participants. Patients were separated into four groups according to NPT results: healthy controls (HC); PD patients with normal cognition (PDNC); PD patients with MCI (PDMCI); and PD patients with dementia (PDD). Analysis of the EEG data showed that HC had the highest alpha activity, and PDD had the lowest. High SMMT scores were correlated with high alpha activity at posterior electrode locations in all PD groups. VLMT and WMS test scores were associated with alpha activity at the parietal sites in PDMCI. VLMT, WMS, and CVFT test scores were correlated with alpha activity at parie-tooccipital sites in PDD. Verbal and visuospatial memory dysfunction related to low alpha activity was evident in both PDMCI and PDD, whereas executive dysfunction was more strongly associated with low alpha activity in PDD. Analysis of alpha activity could help clinicians predict the progression of cognitive dysfunction in PD patients.en_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAlpha Activityen_US
dc.subjectCognitive Dysfunctionen_US
dc.subjectNeuropsychometric Testen_US
dc.subjectParkinson's Diseaseen_US
dc.titleCorrelation between alpha activity and neuropsychometric tests in Parkinson's diseaseen_US
dc.typearticleen_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.authorid0000-0001-7566-1063en_US
dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0003-4292-5717en_US
dc.identifier.volume738en_US
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/214S111
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.neulet.2020.135346en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ2en_US


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