Kurum Yazarı "Çağavi, Esra" Enstitüler İçin Listeleme
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Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach
Kazcı, Yusuf Enes; Şahoğlu Göktaş, Sevilay; Aydın, Mehmet Şerif; Karadoğan, Behnaz; Nebol, Aylin; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Elsevier B.V., 2022)Heart is an extensively innervated organ and its function is strictly coordinated by autonomic neural circuits. After pathological events such as myocardial infarction (MI), cardiac nerves undergo a structural and functional ... -
Functional evaluation of the tachycardia patient-derived iPSC cardiomyocytes carrying a novel pathogenic SCN5A variant
Şahoğlu Göktaş, Sevilay; Kazcı, Yusuf Enes; Tuncay, Erkan; Torun, Tuğçe; Akdeniz, Celal; Tuzcu, Volkan; Çağavi, Esra (Wiley, 2022)Tachycardia is characterized by high beating rates that can lead to life-threatening fibrillations. Mutations in several ion-channel genes were implicated with tachycardia; however, the complex genetic contributors and ... -
High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts
Göktaş Şahoğlu, Sevilay; Kazcı, Yusuf Enes; Karadoğan, Behnaz; Aydın, Mehmet Şerif; Nebol, Aylin; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Wiley, 2023)The sensory nervous system is critical to maintain cardiac function. As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2-expressing cardiac afferent fibers of spinal ... -
Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
Koç, Arzuhan; Akdeniz, Celal; Çağavi, Esra (Springer Heidelberg, 2022)The electrophysiological regulation of cardiomyocytes (CMs) by the cardiac macrophages (M Phi s) has been recently described as an unconventional role of M Phi s in the murine heart. Investigating the molecular and ... -
Replating protocol for human induced pluripotent stem cell–derived cardiomyocytes
Koç, Arzuhan; Çağavi, Esra (Humana Press Inc., 2022)Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational cardiac research. Obtaining hiPSC-CM culture as a single-cell, monolayer or three-dimensional ... -
Revealing nervous and cardiac system interactions by iPSC-Based platforms
Mutlu Burnaz, Özlem; Çağavi, Esra (Elsevier, 2022)Cardiac function is regulated by the autonomic nervous system. In exchange, the sensorial information from the heart is relayed to the brain via sensory neurons as a crucial modulatory feedback mechanism. Cardiovascular ...