Bölüm "İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Moleküler Tıp ve Biyoteknoloji Ana Bilim Dalı" Enstitüler için listeleme
Toplam kayıt 9, listelenen: 1-9
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Cytotoxic activity and docking studies of 2-arenoxybenzaldehyde N-acyl hydrazone and 1,3,4-oxadiazole derivatives against various cancer cell lines
(MDPI, 2022)To understand whether previously synthesized novel hydrazone and oxadiazole derivatives have promising anticancer effects, docking studies and in vitro toxicity assays were performed on A-549, MDA-MB-231, and PC-3 cell ... -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
(Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19
(Springer Science and Business Media Deutschland GmbH, 2023)Favipiravir is a wide-spectrum antiviral generic drug that has received large attention during the recent COVID-19 pandemic. While there are synthetic strategies for favipiravir synthesis, economical procedures could ... -
The effects of increased glucose level and glycolysis on SARS CoV-2 infection
(Bentham Science Publishers, 2022)COVID-19 has entered our lives as an infection with high mortality rates. Although the vaccination process has provided benefits, the death toll remains frightening worldwide. Therefore, drugs and combined therapies that ... -
Investigation of anticancer activities of potentially active small molecule drug candidate molecules
(İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Cancer is defined as the uncontrolled division and proliferation of cells in any part of the body. The most frequently seen cancers are lung, breast, and prostate cancer. Small molecules can be used for treatment of cancer. ... -
Lamotrigine derivatives-synthesis, anti-cancer, and anti-MDR-bacterial activities
(Elsevier B.V., 2022)A new series of quaternary ammonium salts 3–21 of lamotrigine (6-(2, 3-dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine) was synthesized via N-alkylation of lamotrigine using different benzyl bromides. The new analogues were ... -
Metaproteomic analysis of saliva samples from parkinson's disease patients with cognitive impairments
(İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Parkinson's Disease (PD) is a NeuroDegenerative Disease (NDD) that includes impairment and death of dopaminergic neurons at the brain and alpha-synuclein (α-syn) protein accumulation (Lewy bodies). PD symptoms include both ... -
A rational design of multi-functional nanoplatform: Fluorescent-based “off-on” theranostic gold nanoparticles modified with D-α-Tocopherol succinate
(Elsevier B.V., 2021)It is crucial to develop nanocarrier systems to detect and treat drug-resistant micro tumors to prevent recurrence and/or metastasis of cancer. Due to their exceptional features such as biocompatibility, easy surface ... -
Stimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release
(Elsevier B.V., 2022)Destruction of drug resistant and invisible micro-tumors requires innovative screening and treatment modalities. Theranostic nanosystems offering multimodal imaging and therapy are attractive platforms with potential to ...