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dc.contributor.authorAkgül, Özgür
dc.contributor.authorBodur, Hatice
dc.contributor.authorAtaman, Şebnem
dc.contributor.authorYurdakul, Fatma Gül
dc.contributor.authorÇapkın, Erhan
dc.contributor.authorGürer, Gülcan
dc.contributor.authorSezer, İlhan
dc.contributor.authorDuruöz, Mehmet Tuncay
dc.contributor.authorAlkan Melikoğlu, Meltem
dc.contributor.authorÇay, Hasan Fatih
dc.contributor.authorRezvani, Aylin
dc.contributor.authorYağcı, İlker
dc.contributor.authorGöğüs, Feride
dc.contributor.authorKamanlı, Ayhan
dc.contributor.authorÇevik, Remzi
dc.date.accessioned2020-10-27T10:47:12Z
dc.date.available2020-10-27T10:47:12Z
dc.date.issued2020en_US
dc.identifier.citationAkgül, Ö., Bodur, H., Ataman, Ş., Yurdakul, F. G., Çapkın, E., Gürer, G. ... Çevik, R. (2020). Clinical performance of ASAS health index in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: Real-world evidence from Multicenter Nationwide Registry. Rheumatology International, 40(11), 1793-1801. https://dx.doi.org/10.1007/s00296-020-04680-8en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.urihttps://dx.doi.org/10.1007/s00296-020-04680-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5983
dc.description.abstractThe Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is used as a new instrument in measuring the function, disability and health of patients with spondyloarthritis (SpA). However, the real-world evidence of ASAS HI is very limited. In the present study, our objective is to evaluate the psychometric properties and performance of ASAS HI in the real-world setting as well as comparing ASAS HI with the current instruments to assess the construct validity and determine the cut-off points in patients with both ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). A total of 991 patients with axSpA who fulfilled either the ASAS classification criteria for axial SpA (axSpA) or the Modified New York Criteria (mNY) for AS were recruited from the Biologic and targeted Synthetic antirheumatic drugs Registry (BioStaR) SpA. The construct validity of ASAS HI against the Bath Ankylosing Spondylitis Disease Activities Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein (ASDAS-CRP) the Bath Ankylosing Spondylitis Functional index (BASFI) was performed. Using the receiver operating characteristic (ROC) curves analysis, the cut-off points were calculated. Of all the recruited patients, 851 (85.9%) were AS and 140 (14.1%) were nr-axSpA. The difference in the mean ASAS HI scores of the patients with AS and the ones with nr-axSpA were not statistically significant (6.12 +/- 4.29 and 6.42 +/- 4.86, respectively). The mean ASAS HI score was significantly higher in females and small city residents. The ASAS HI had a strong construct validity against ASDAS-CRP, BASDAI and BASFI. A cut-off point of <= 4 was determined to discriminate good and moderate, as well as >= 12 to discriminate moderate and poor health status. In conclusion, ASAS HI is a reliable instrument to evaluate health and functioning for both patients with AS and nr-axSpA in clinical practice.en_US
dc.description.sponsorshipTurkish League Against Rheumatism (TLAR)en_US
dc.language.isoengen_US
dc.publisherSpringer Heidelbergen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectHealth Status Indexen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectHealth-Related Quality of Lifeen_US
dc.subjectFunctional Performanceen_US
dc.titleClinical performance of ASAS health index in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: Real-world evidence from Multicenter Nationwide Registryen_US
dc.typearticleen_US
dc.relation.journalRheumatology Internationalen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalıen_US
dc.authorid0000-0002-5852-3854en_US
dc.identifier.volume40en_US
dc.identifier.issue11en_US
dc.identifier.startpage1793en_US
dc.identifier.endpage1801en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00296-020-04680-8en_US


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