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dc.contributor.authorKeshvari-Shad, Fatemeh
dc.contributor.authorHajebrahimi, Sakineh
dc.contributor.authorPes, Maria Pilar Laguna
dc.contributor.authorMahboub-Ahari, Alireza
dc.contributor.authorNouri, Mohammad
dc.contributor.authorSeyednejad, Farshad
dc.contributor.authorYousefi, Mahmood
dc.date.accessioned2020-08-13T06:06:19Z
dc.date.available2020-08-13T06:06:19Z
dc.date.issued2020en_US
dc.identifier.citationKeshvari-Shad, F., Hajebrahimi, S., Pes, M. P. L., Mahboub-Ahari, A., Nouri, M., Seyednejad, F. ... Yousefi, M. (2020). A Systematic review of screening tests for chronic kidney disease: An accuracy analysis. Galen Medical Journal, 9. https://dx.doi.org/10.31661/gmj.v9i0.1573en_US
dc.identifier.issn2588-2767
dc.identifier.issn2322-2379
dc.identifier.urihttps://dx.doi.org/10.31661/gmj.v9i0.1573
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5707
dc.description.abstractThis systematic review was conducted to assess the diagnostic accuracy of chronic kidney disease screening tests in the general population. MEDLINE, EMBASE, Web of Science, Scopus, The Cochrane Library and ProQuest databases were searched for English-language publications up to November 2016. Two reviewers independently screened studies and extracted study data in standardized tables. Methodological quality was assessed using the QUADAS-2 tool. Sensitivity and specificity of all available screening methods were identified through included studies. Ten out of 1349 screened records included for final analysis. Sensitivities of the dipstick test with a cutoff value of trace were ranged from 37.1% to 69.4% and specificities from 93.7% to 97.3% for the detection of ACR>30 mg/g. The diagnostic sensitivities of the UAC>10 mg/dL testing was shown to vary from 40% to 87%, and specificities ranged from 75% to 96%. While the sensitivities of ACR were fluctuating between 74% and 90%, likewise the specificities were between 77% and 88%. Sensitivities for C-G, Grubb and Larsson equations were 98.9%, 86.2%, and 70.1% respectively. In the meantime the study showed specificities of 84.8%, 84.2% and 90.5% respectively for these equations. Individual studies were highly heterogeneous in terms of target populations, type of screening tests, thresholds used to detect CKD and variations in design. Results pointed to the superiority of UAC and dipstick over the other tests in terms of all parameters involved. The diversity of methods and thresholds for detection of CKD, necessitate considering the cost parameter along with the effectiveness of tests to scale-up an efficient strategy.en_US
dc.description.sponsorshipTabriz University of Medical Sceinecsen_US
dc.language.isoengen_US
dc.publisherSalvia Medical Sciences Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectChronic Kidney Diseaseen_US
dc.subjectScreeningen_US
dc.subjectSensitivityen_US
dc.subjectSpecificityen_US
dc.subjectSystematic Reviewen_US
dc.titleA Systematic review of screening tests for chronic kidney disease: An accuracy analysisen_US
dc.typereviewen_US
dc.relation.journalGalen Medical Journalen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalıen_US
dc.authorid0000-0003-0906-4417en_US
dc.identifier.volume9en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.31661/gmj.v9i0.1573en_US


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