Erratum to: Mutant SOD1 protein increases Na(v)1.3 channel excitability
AuthorKubat Öktem, Elif
R. Kobertz, William
Brown Jr, Robert H.
MetadataShow full item record
CitationKubat Öktem, E., Mruk, K., Chang, J., Akın, A., R. Kobertz, W. ve Brown Jr, R. H. (2016). Erratum to: Mutant SOD1 protein increases Na(v)1.3 channel excitability. Journal of Biological Physics , 42(3), 371. http://dx.doi.org/10.1007/s10867-016-9421-8
Firing patterns of a mammalian neuron in response to changes in Nav conductance induced by hSOD1A4V. a At the baseline (see Methods), there is no predicted spontaneous firing as modeled using NEURON software (left; resting membrane potential −62 mV). Transition from silence to firing was observed first at a conductance of 0.29 Siemens/cm2 (right). b When the Nav conductance in the model is increased by 90% (from 0.25 to 0.475 Siemens/cm2 , which is the mean increment in conductance recorded experimentally), the model fires spontaneously (left).