Erratum to: Mutant SOD1 protein increases Na(v)1.3 channel excitability
Künye
Kubat Öktem, E., Mruk, K., Chang, J., Akın, A., R. Kobertz, W. ve Brown Jr, R. H. (2016). Erratum to: Mutant SOD1 protein increases Na(v)1.3 channel excitability. Journal of Biological Physics , 42(3), 371-371. http://dx.doi.org/10.1007/s10867-016-9421-8Özet
Firing patterns of a mammalian neuron in response to changes in Nav conductance induced by hSOD1A4V. a At the baseline (see Methods), there is no predicted spontaneous firing as modeled using NEURON software (left; resting membrane potential −62 mV). Transition from silence to firing was observed first at a conductance of 0.29 Siemens/cm2 (right). b When the Nav conductance in the model is increased by 90% (from 0.25 to 0.475 Siemens/cm2 , which is the mean increment in conductance recorded experimentally), the model fires spontaneously (left).