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dc.contributor.authorKeleştemur, Taha
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorÇağlayan, Ahmet Burak
dc.contributor.authorÇağlayan, Berrak
dc.contributor.authorAltunay, Serdar
dc.contributor.authorKutlu, Selim
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2020-08-05T09:17:34Z
dc.date.available2020-08-05T09:17:34Z
dc.date.issued2020en_US
dc.identifier.citationKeleştemur, T., Beker, M. Ç., Çağlayan, A. B., Çağlayan, B., Altunay, S., Kutlu, S. ... Kılıç, E. (2020). Normobaric oxygen treatment improves neuronal survival functional recovery and axonal plasticity after newborn hypoxia-ischemia. Behavioural Brain Research, 379. https://dx.doi.org/10.1016/j.bbr.2019.112338en_US
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549
dc.identifier.urihttps://dx.doi.org/10.1016/j.bbr.2019.112338
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5669
dc.description.abstractBackground: Newborn hypoxia ischemia (HI) is one of the most prevalent cases in the emergency and can result from fetal hypoxia during delivery. In HI, restricted blood supply to the fetal brain may cause epilepsy or mental disorders.Methods: In the present study, seven-day-old pups were subjected HI and treated with different normobaric oxygen (NBO) concentrations (21%, 70% or 100%). In the acute phase, we analyzed infarct area, disseminate neuronal injury and surviving neurons. In addition, we studied the regulation of PTEN and MMP-9 proteins which were suggested to be activated by HI in the ischemic tissue. Moreover, long-term effects of NBO treatments were evaluated with open field, rotarod and Barnes maze tests. We also examined axonal plasticity with EGFP-AAV injection.Results: Here, we demonstrate that hyperoxic NBO concentration causes an increase in cellular survival and a decrease in the number of apoptotic cells, meanwhile inhibiting the proteins involved in cellular death mechanisms. Moreover, we found that hyperoxia decreases anxiety, promotes motor coordination and improve spatial learning and memory. Notably that axonal sprouting was promoted by hyperoxia.Conclusion: Our data suggest that NBO is a promising approach for the treatment of newborn HI, which encourage proof-of-concept studies in newborn.en_US
dc.description.sponsorshipTurkish Academy of Sciences Necmettin Erbakan Universityen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectFunctional Recoveryen_US
dc.subjectMMP-9en_US
dc.subjectNewborn Hypoxia Ischemiaen_US
dc.subjectNormobaric Oxygenen_US
dc.subjectPlasticityen_US
dc.subjectPTENen_US
dc.titleNormobaric oxygen treatment improves neuronal survival functional recovery and axonal plasticity after newborn hypoxia-ischemiaen_US
dc.typearticleen_US
dc.relation.ispartofBehavioural Brain Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-3616-1204en_US
dc.authorid0000-0002-9476-8488en_US
dc.authorid0000-0002-6242-3709en_US
dc.authorid0000-0002-5072-132Xen_US
dc.authorid0000-0002-4051-2559en_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume379en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.bbr.2019.112338en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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