dc.contributor.author | Keleştemur, Taha | |
dc.contributor.author | Beker, Mustafa Çağlar | |
dc.contributor.author | Çağlayan, Ahmet Burak | |
dc.contributor.author | Çağlayan, Berrak | |
dc.contributor.author | Altunay, Serdar | |
dc.contributor.author | Kutlu, Selim | |
dc.contributor.author | Kılıç, Ertuğrul | |
dc.date.accessioned | 2020-08-05T09:17:34Z | |
dc.date.available | 2020-08-05T09:17:34Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Keleştemur, T., Beker, M. Ç., Çağlayan, A. B., Çağlayan, B., Altunay, S., Kutlu, S. ... Kılıç, E. (2020). Normobaric oxygen treatment improves neuronal survival functional recovery and axonal plasticity after newborn hypoxia-ischemia. Behavioural Brain Research, 379. https://dx.doi.org/10.1016/j.bbr.2019.112338 | en_US |
dc.identifier.issn | 0166-4328 | |
dc.identifier.issn | 1872-7549 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.bbr.2019.112338 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5669 | |
dc.description.abstract | Background: Newborn hypoxia ischemia (HI) is one of the most prevalent cases in the emergency and can result from fetal hypoxia during delivery. In HI, restricted blood supply to the fetal brain may cause epilepsy or mental disorders.Methods: In the present study, seven-day-old pups were subjected HI and treated with different normobaric oxygen (NBO) concentrations (21%, 70% or 100%). In the acute phase, we analyzed infarct area, disseminate neuronal injury and surviving neurons. In addition, we studied the regulation of PTEN and MMP-9 proteins which were suggested to be activated by HI in the ischemic tissue. Moreover, long-term effects of NBO treatments were evaluated with open field, rotarod and Barnes maze tests. We also examined axonal plasticity with EGFP-AAV injection.Results: Here, we demonstrate that hyperoxic NBO concentration causes an increase in cellular survival and a decrease in the number of apoptotic cells, meanwhile inhibiting the proteins involved in cellular death mechanisms. Moreover, we found that hyperoxia decreases anxiety, promotes motor coordination and improve spatial learning and memory. Notably that axonal sprouting was promoted by hyperoxia.Conclusion: Our data suggest that NBO is a promising approach for the treatment of newborn HI, which encourage proof-of-concept studies in newborn. | en_US |
dc.description.sponsorship | Turkish Academy of Sciences
Necmettin Erbakan University | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Functional Recovery | en_US |
dc.subject | MMP-9 | en_US |
dc.subject | Newborn Hypoxia Ischemia | en_US |
dc.subject | Normobaric Oxygen | en_US |
dc.subject | Plasticity | en_US |
dc.subject | PTEN | en_US |
dc.title | Normobaric oxygen treatment improves neuronal survival functional recovery and axonal plasticity after newborn hypoxia-ischemia | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Behavioural Brain Research | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-3616-1204 | en_US |
dc.authorid | 0000-0002-9476-8488 | en_US |
dc.authorid | 0000-0002-6242-3709 | en_US |
dc.authorid | 0000-0002-5072-132X | en_US |
dc.authorid | 0000-0002-4051-2559 | en_US |
dc.authorid | 0000-0001-6494-8923 | en_US |
dc.identifier.volume | 379 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.bbr.2019.112338 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |