dc.contributor.author | Mataracı Kara, Emel | |
dc.contributor.author | Yılmaz, Mesut | |
dc.contributor.author | İstanbullu Tosun, Ayşe | |
dc.contributor.author | Özbek Çelik, Berna | |
dc.date.accessioned | 2020-07-28T10:31:57Z | |
dc.date.available | 2020-07-28T10:31:57Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Mataracı Kara, E., Yılmaz, M., İstanbullu Tosun, A. ve Özbek Çelik, B. (2020). Synergistic activities of ceftazidime-avibactam in combination with different antibiotics against colistin-nonsusceptible clinical strains of Pseudomonas aeruginosa. Infectious Diseases, 52(9), 616-624. https://dx.doi.org/10.1080/23744235.2020.1767803 | en_US |
dc.identifier.issn | 2374-4235 | |
dc.identifier.issn | 2374-4243 | |
dc.identifier.uri | https://dx.doi.org/10.1080/23744235.2020.1767803 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5625 | |
dc.description.abstract | Background: This study aims to analyse the effect of ceftazidime-avibactam plus various antibiotics against multidrug-resistant (MDR) Pseudomonas aeruginosa isolated from Intensive Care Units. Methods: 40 non-duplicate P. aeruginosa isolates were screened for their MICs of ceftazidime, ceftazidime-avibactam, colistin, levofloxacin, doripenem and tobramycin. MICs were determined by the broth microdilution method. The in vitro bactericidal activities of ceftazidime-avibactam compared to studied antibiotics were also determined by time-kill curve assays both at 1xMIC and at 4xMIC against carbapenemase-producing or -not producing six colistin-nonsusceptible MDR clinical strains of P. aeruginosa. Additionally, synergistic interactions were investigated by the time-kill curve assay. Results: The MIC90 values for ceftazidime, ceftazidime-avibactam, colistin, levofloxacin, doripenem and tobramycin against MDR P. aeruginosa isolates were found to be >256, 64, 8, 64, 128, and >256 mg/L, respectively. The minimum bactericidal concentration(90) values for those antibiotics were also >256, 64, 16, 128, 256, and >256 mg/L, respectively. While doripenem, tobramycin and levofloxacin were bactericidal (>3 log(10) killing) against the 2/6, 3/6 and 1/6 P. aeruginosa isolates at 4xMIC concentrations, respectively, levofloxacin and tobramycin were bactericidal against only one isolate (1/6) at 1xMIC concentrations at 24 h. The synergistic interactions of these antimicrobial agents were also achieved with ceftazidime/avibactam + colistin (4/6), ceftazidime/avibactam + tobramycin (3/6), and ceftazidime/avibactam + levofloxacin (3/6) combinations. No antagonism was observed against studied P. aeruginosa strains. Conclusions: The findings of this study suggest that ceftazidime/avibactam with colistin, or tobramycin, were effective against colistin-nonsusceptible strains. This combination therapy could be an alternative antibiotic therapy for resistant P. aeruginosa strains. | en_US |
dc.description.sponsorship | Istanbul University | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis Ltd. | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Ceftazidime-Avibactam | en_US |
dc.subject | OXA-48 | en_US |
dc.subject | Colistin Resistance | en_US |
dc.subject | Pseudomonas Aeruginosa | en_US |
dc.subject | Synergy | en_US |
dc.title | Synergistic activities of ceftazidime-avibactam in combination with different antibiotics against colistin-nonsusceptible clinical strains of Pseudomonas aeruginosa | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Infectious Diseases | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-8022-7325 | en_US |
dc.authorid | 0000-0003-3952-1914 | en_US |
dc.identifier.volume | 52 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 616 | en_US |
dc.identifier.endpage | 624 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1080/23744235.2020.1767803 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q2 | en_US |