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Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study

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Date

2020

Author

Babiloni, Claudio
Pascarelli, Maria Teresa
Lizio, Roberta
Noce, Giuseppe
Lopez, Susanna
Rizzo, Marco
Ferri, Raffaele
Soricelli, Andrea
Nobili, Flavio
Arnaldi, Dario
Fama, Francesco
Orzi, Francesco
Buttinelli, Carla
Giubilei, Franco
Salvetti, Marco
Cipollini, Virginia
Bonanni, Laura
Franciotti, Raffaella
Onofrj, Marco
Stirpe, Paola
Fuhr, Peter
Gschwandtner, Ute
Ransmayr, Gerhard
Aarsland, Dag
Parnetti, Lucilla
Farotti, Lucia
Marizzoni, Moira
D'Antonio, Fabrizia
De Lena, Carlo
Güntekin, Bahar
Hanoğlu, Lütfü
Yener, Görsev
Emek-Savaş, Derya Durusu
Triggiani, Antonio Ivano
Taylor, John Paul
McKeith, Ian
Stocchi, Fabrizio
Vacca, Laura
Hampel, Harald
Frisoni, Giovanni B.
De Pandis, Maria Francesca
Del Percio, Claudio

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Babiloni, C., Pascarelli, M. T., Lizio, R., Noce, G., Lopez, S., Rizzo, M. ... Del Percio, C. (2020). Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study. Neurobiology of Aging, 91, 88-111. https://dx.doi.org/10.1016/j.neurobiolaging.2020.02.029

Abstract

Compared with Alzheimer's disease (AD), Parkinson's disease (PD) shows peculiar clinical manifestations related to vigilance (i.e., executive cognitive deficits and visual hallucinations) that may be reflected in resting-state electroencephalographic rhythms. To test this hypothesis, clinical and resting-state electroencephalographic rhythms in age-, sex-, and education-matched PD patients (N = 136) and Alzheimer's disease patients (AD, N = 85), and healthy older participants (Nold, N = 65), were available from an international archive. Electroencephalographic sources were estimated by eLORETA software. The results are as follows: (1) compared to the Nold participants, the AD and PD patients showed higher widespread delta source activities (PD > AD) and lower posterior alpha source activities (AD > PD); (2) the PD patients with the most pronounced motor deficits exhibited very low alpha source activities in widespread cortical regions; (3) the PD patients with the strongest cognitive deficits showed higher alpha source activities in widespread cortical regions; and (4) compared to the PD patients without visual hallucinations, those with visual hallucinations were characterized by higher posterior alpha sources activities. These results suggest that in PD patients resting in quiet wakefulness, abnormalities in cortical neural synchronization at alpha frequencies are differently related to cognitive, motor, and visual hallucinations. Interestingly, parallel PD neuropathological processes may have opposite effects on cortical neural synchronization mechanisms generating cortical alpha rhythms in quiet wakefulness.

WoS Q Kategorisi

Q2

Source

Neurobiology of Aging

Volume

91

URI

https://dx.doi.org/10.1016/j.neurobiolaging.2020.02.029
https://hdl.handle.net/20.500.12511/5610

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  • Makale Koleksiyonu [3079]
  • Makale Koleksiyonu [248]
  • PubMed İndeksli Yayınlar Koleksiyonu [3361]
  • Scopus İndeksli Yayınlar Koleksiyonu [5122]
  • WoS İndeksli Yayınlar Koleksiyonu [5378]



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