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dc.contributor.authorDiker, Nurettin
dc.contributor.authorÇağlayan, Berrak
dc.contributor.authorHelvacıoğlu, Fatma
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2020-07-13T06:55:20Z
dc.date.available2020-07-13T06:55:20Z
dc.date.issued2020en_US
dc.identifier.citationDiker, N., Çağlayan, B., Helvacıoğlu, F. ve Kılıç, E. (2020). The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury. European Journal of Oral Sciences, 128(3), 183-189. https://dx.doi.org/10.1111/eos.12691en_US
dc.identifier.issn0909-8836
dc.identifier.issn1600-0722
dc.identifier.urihttps://dx.doi.org/10.1111/eos.12691
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5460
dc.description.abstractAxonal regeneration of the inferior alveolar nerve (IAN) is a therapeutic target for functional recovery after peripheral nerve injury. Rifampicin exerts anti-apoptotic, anti-inflammatory, and anti-oxidant effects on nerve tissues that may enhance functional recovery after peripheral nerve injury. The aim of the present study was to evaluate the therapeutic effects of systemic rifampicin following IAN crush injury. Following the nerve crush injuries of the IAN, 24 Sprague-Dawley rats were randomly divided into three groups to receive daily intraperitoneal injections of either vehicle, 5 mg kg(-1) rifampicin, or 20 mg kg(-1) rifampicin. Twenty-four days after induction of nerve injuries, Fluorogold (FG) was injected over the mental foramen for the evaluation of neuronal survival. At the end of the four-week period, histologic and histomorphometric examination of IAN samples were performed and FG positive cells were counted in the trigeminal ganglion sections. FG positive cells were significantly more frequent in the 20 and 5 mg kg(-1) rifampicin groups than in the vehicle-treated group. Electron microscopic analyses revealed that the percentage of axons with optimum g-ratio was significantly lower in the vehicle group than in both treatment groups. In conclusion, systemic rifampicin treatment can enhance peripheral nerve regeneration.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectMandibular Nerveen_US
dc.subjectNerve Regenerationen_US
dc.subjectRifampicinen_US
dc.subjectTrigeminal Ganglionen_US
dc.titleThe effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injuryen_US
dc.typearticleen_US
dc.relation.ispartofEuropean Journal of Oral Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-7825-1083en_US
dc.authorid0000-0002-5072-132Xen_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume128en_US
dc.identifier.issue3en_US
dc.identifier.startpage183en_US
dc.identifier.endpage189en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/eos.12691en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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