The relationship of arginophilic proteins of the nuclear organized regions and atopic dermatitis in children
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info:eu-repo/semantics/embargoedAccessTarih
2019Yazar
Gündüz, MehmetOkur, Mesut
Aksoy Okan, Meliha
Şengil, Ahmet Zeki
Temel, Hayrettin
Cömert, Murat
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Gündüz, M., Okur, M., Aksoy Okan, M., Şengil, Ahmet Z., Temel, H. ve Cömert, M. (2019). The relationship of arginophilic proteins of the nuclear organized regions and atopic dermatitis in children. Experimental Dermatology, 28(11), 1309-1312. https://dx.doi.org/10.1111/exd.14031Özet
Backround: The arginophilic proteins of nuclear organized regions (AgNOR), visualized with colloidal silver methods as black dots are known as AgNOR. To date, the relationship between AgNOR and cancer and inflammatory conditions has been investigated. However, there has been no report investigating the relationship between AgNOR and atopic dermatitis. The aim of this study was to investigate the relationship between atopic dermatitis and AgNOR in paediatric patients. Methods: Twenty-nine children with atopic dermatitis and 23 healthy children were included in the study. AgNOR test results were analysed prospectively. Results: The mean AgNOR number (40.19 +/- 21.06) in the patient group was significantly higher than the control group (12.83 +/- 10.40) (P<.001). Conclusions: This study investigated the association between AgNOR and atopic dermatitis for the first time in the literature. In the study, atopic dermatitis and AgNOR were found to be related. In the study, for the first time with the ROC analysis, AgNOR limit values with high sensitivity and specificity levels were determined in the diagnosis of atopic dermatitis.
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Experimental DermatologyCilt
28Sayı
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