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dc.contributor.authorŞimşek, Selen Burçak
dc.contributor.authorÇayır Keleş, Gonca
dc.contributor.authorBarış, Sancar
dc.contributor.authorÖzkan Çetinkaya, Burcu
dc.date.accessioned2020-06-01T09:18:49Z
dc.date.available2020-06-01T09:18:49Z
dc.date.issued2012en_US
dc.identifier.citationŞimşek, S. B., Çayır Keleş, G., Barış, S. ve Özkan Çetinkaya, B. (2012). Comparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogs. Clinical Oral Investigations, 16(1), 251-258. https://dx.doi.org/10.1007/s00784-010-0486-7en_US
dc.identifier.issn1432-6981
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5245
dc.identifier.urihttps://dx.doi.org/10.1007/s00784-010-0486-7
dc.description.abstractThe purpose of this study was to compare the effectiveness of mesenchymal stem cells (MSCs) with platelet-rich plasma (PRP) as scaffold and autogenous cortical bone (ACB) graft with and without PRP in the regenerative treatment of class II furcation defects in dogs. The mandibular second, third, and fourth premolars (P2, P3, P4) and maxillary P3 and P4 of both sides in three dogs were selected for experimentation. Class II furcation defects (5 mm in height and 2 mm in depth) were surgically created. Five weeks after the first operation, scaling + root planning (group 1), PRP (group 2), ACB (group 3), combination of ACB/PRP (group 4), and combination of MSCs/PRP (group 5) treatments were performed during open flap debridement. The percentage of cementum and alveolar bone formation was evaluated by histomorphometric analysis after a healing period of 8 weeks. There was new cementum along with periodontal ligament and coronal growth of alveolar bone in all groups. Cementum formation was significantly higher in groups 3, 4, and 5 compared to the control group (P < 0.05) with no significant difference between groups 2, 3, 4, and 5. Alveolar bone formation was similar in all groups (P > 0.05). It can be concluded that periodontal regeneration with complete filling of class II furcation defects with cementum, alveolar bone, and periodontal ligament is obtained 8 weeks after ACB, ACB/PRP, and MSCs/PRP treatments; however, efficacy of none is higher than another.en_US
dc.description.sponsorshipOndokuz Mayis Universityen_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAutogenous Bone Graften_US
dc.subjectFurcation Defectsen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectPeriodontal Regenerationen_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.titleComparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogsen_US
dc.typearticleen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.identifier.volume16en_US
dc.identifier.issue1en_US
dc.identifier.startpage251en_US
dc.identifier.endpage258en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00784-010-0486-7en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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