dc.contributor.author | Karahan, Nazım | |
dc.contributor.author | Özdemir, Güzelali | |
dc.contributor.author | Kolukısa, Duygu | |
dc.contributor.author | Duman, Serda | |
dc.contributor.author | Arslanoǧlu, Fatih | |
dc.contributor.author | Çetin, Mehmet | |
dc.date.accessioned | 2020-04-16T08:48:45Z | |
dc.date.available | 2020-04-16T08:48:45Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Karahan, N., Özdemir, G., Kolukısa, D., Duman, S., Arslanoǧlu, F. ve Çetin, M. (2020). Can collagenase be used in the treatment of adhesive capsulitis? Medical Principles and Practice, 29(2), 174-180. https://dx.doi.org/10.1159/000503086 | en_US |
dc.identifier.issn | 1011-7571 | |
dc.identifier.issn | 1423-0151 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5131 | |
dc.identifier.uri | https://dx.doi.org/10.1159/000503086 | |
dc.description.abstract | Background: The objective of this study was to evaluate the efficacy of subacromial injections of collagenase and corticosteroid in rats with experimentally induced adhesive capsulitis. Method: Thirty adult Wistar albino male rats were distributed into 3 groups of 10 rats each after stabilization of their shoulders for 3 weeks: the first group received a single dose of 0.002 mg (0.25 mL) subacromial collagenase; the second group received a single dose of 1.60 mg (0.25 mL) subacromial steroid, and the third group received a single dose of 0.25 mL subacromial saline solution. One week later, we investigated shoulder range of motions, collagen content of the shoulder, and joint cartilage structure. Results: There was no statistically significant difference in the cartilage damage between the groups (p > 0.05). Fibrosis measurements were significantly lower in the collagenase group than in the steroid and saline groups. There was no significant difference in fibrosis between the steroid and saline groups (p > 0.05). Abduction measurements were significantly higher in the collagenase group than in the steroid and saline groups (p < 0.001). No significant difference in the abduction measurements was observed between the saline and steroid groups (p > 0.05). Conclusion: We observed that subacromial injections of collagenase Clostridium histolyticum effectively treated adhesive capsulitis. The results suggest that this treatment could be considered for use in patients with an intact rotator cuff. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Adhesive Capsulitis | en_US |
dc.subject | Collagenase | en_US |
dc.subject | Experimental Study | en_US |
dc.subject | Rat | en_US |
dc.subject | Steroid | en_US |
dc.title | Can collagenase be used in the treatment of adhesive capsulitis? | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Medical Principles and Practice | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 174 | en_US |
dc.identifier.endpage | 180 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1159/000503086 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q3 | en_US |