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dc.contributor.authorGirit, Saniye
dc.contributor.authorAyzıt Atabek, Ayşe
dc.contributor.authorŞenol, Ebru
dc.contributor.authorKoçkar Kızılırmak, Tuba
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorGöktaş, Şafak
dc.contributor.authorÖktem, Sedat
dc.contributor.authorKasapçopur, Özgür
dc.contributor.authorÇokuğraş, Haluk
dc.date.accessioned2020-04-13T07:41:36Z
dc.date.available2020-04-13T07:41:36Z
dc.date.issued2020en_US
dc.identifier.citationGirit, S., Ayzıt Atabek, A., Şenol, E., Koçkar Kızılırmak, T., Pekcan, S., Göktaş, Ş. ... Çokuğraş, H. (2020). Screening for latent tuberculosis in children with immune-mediated inflammatory diseases treated with anti-tumor necrosis factor therapy: Comparison of tuberculin skin and T-SPOT tuberculosis tests. Archives of Rheumatology, 35(1), 20-28. https://dx.doi.org/10.5606/ArchRheumatol.2020.7294en_US
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5105
dc.identifier.urihttps://dx.doi.org/10.5606/ArchRheumatol.2020.7294
dc.description.abstractObjectives: This study aims to analyze the coherence between T-SPOT tuberculosis test (T-SPOT.TB) and tuberculin skin test (TST) with different cut-off values in screening latent tuberculosis infection (LTBI) both prior to and at the sixth month of anti-tumor necrosis factor (anti-TNF) treatment.Patients and methods: This prospective multicentric study included 57 children (34 girls, 23 boys, mean age 12.4 +/- 3.9 years; range, 6 to 18 years) diagnosed with immune-mediated inflammatory diseases (IMIDs) evaluated with TST and T-SPOT.TB for screening LTBI both prior to and at the sixth month of treatment with anti-TNF agents. Coherence between two tests was analyzed for TST cut-off values suggested by the local guidelines and also for different possible cut-off values of TST.Results: Tuberculin skin test was positive (>= 5 mm) in 28.1% (n=16) of patients in the screening prior to treatment and in 33.3% (n=19) at the sixth month of treatment. T-SPOT.TB test was positive in 8.8% (n=5) of patients both prior to and at the sixth month of treatment. Coherence between two tests was poor or fair when compared with all possible TST cut-off values both prior to and at the sixth month of anti-TNF therapy.Conclusion: Our results show poor coherence between T-SPOT.TB and TST for all possible cut- off values of TST. Thus, using both tests would be beneficial in screening LTBI until further studies bring new evidence on the subject.en_US
dc.language.isoengen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChilden_US
dc.subjectİmmune System Diseaseen_US
dc.subjectİnterferon-Gamma Release Assayen_US
dc.subjectLatent Tuberculosisen_US
dc.subjectTuberculin Skin Testen_US
dc.titleScreening for latent tuberculosis in children with immune-mediated inflammatory diseases treated with anti-tumor necrosis factor therapy: Comparison of tuberculin skin and T-SPOT tuberculosis testsen_US
dc.typearticleen_US
dc.relation.journalArchives of Rheumatologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-6819-3887en_US
dc.authorid0000-0002-7950-2067en_US
dc.identifier.volume35en_US
dc.identifier.issue1en_US
dc.identifier.startpage20en_US
dc.identifier.endpage28en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5606/ArchRheumatol.2020.7294en_US


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