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dc.contributor.authorGüler, Ekrem
dc.contributor.authorGüler, Gamze Babür
dc.contributor.authorDemir, Gültekin Günhan
dc.contributor.authorHatipoǧlu, Suzan
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:18:51Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:18:51Z
dc.date.issued2015en_US
dc.identifier.citationGüler, E., Güler, G. B., Demir, G. G. ve Hatipoǧlu, S. (2015). A review of the fixed dose use of new oral anticoagulants in obese patients: Is it really enough? The Anatolian Journal of Cardiology, (15)2, 1020-1029. https://doi.org/10.5152/AnatolJCardiol.2015.6532en_US
dc.identifier.issn2149-2263
dc.identifier.urihttps://hdl.handle.net/20.500.12511/505
dc.identifier.urihttps://doi.org/10.5152/AnatolJCardiol.2015.6532
dc.description.abstractObesity is a significant cause of morbidity and mortality, and it is becoming increasingly prevalent worldwide. Altered pharmacodynamics and pharmacokinetics of drugs in obese patients require dose adjustment according to body weight. New oral anticoagulants (NOACs), which are more frequently used for anticoagulation, are recommended to be used at a fixed dose based on data derived from phase 2 and 3 studies. However, the representation of obese patients [>100 kg or a body mass index (BMI) of >30 kg/m] in subgroups with a small sample size and reports of various emboli cases under drug treatment have raised suspicions about the adequacy of fixed dose use. To address this issue, we analyzed several patients with a body weight of >100 kg or BMI of >30 kg/m participating in NOAC studies and evaluated whether these numbers were sufficient to enable an accurate recommendation of fixed dose use in obese patients.en_US
dc.language.isoengen_US
dc.publisherAVESen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectAnticoagulantsen_US
dc.subjectFactor xa Inhibitoren_US
dc.subjectDabigatranen_US
dc.subjectOralen_US
dc.subjectFixed Doseen_US
dc.titleA review of the fixed dose use of new oral anticoagulants in obese patients: Is it really enough?en_US
dc.typeotheren_US
dc.relation.journalThe Anatolian Journal of Cardiologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-4607-5724en_US
dc.authorid0000-0001-9975-5507en_US
dc.identifier.volume15en_US
dc.identifier.issue12en_US
dc.identifier.startpage1020en_US
dc.identifier.endpage1029en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5152/AnatolJCardiol.2015.6532en_US


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