dc.contributor.author | Altıntaş, Özge | |
dc.contributor.author | Antar, Veysel | |
dc.contributor.author | Baran, Oğuz | |
dc.contributor.author | Karataş, Ersin | |
dc.contributor.author | Altıntaş, Mehmet Özgen | |
dc.contributor.author | Kesgin, Sıdıka | |
dc.contributor.author | Büyükpınarbaşılı, Nur | |
dc.contributor.author | Koçyiğit, Abdurrahim | |
dc.contributor.author | Asil, Talip | |
dc.date.accessioned | 2020-03-11T07:27:06Z | |
dc.date.available | 2020-03-11T07:27:06Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Altıntaş, Ö., Antar, V., Baran, O., Karataş, E., Altıntaş, M. Ö., Kesgin, S. ... Asil, T. (2019). Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: Experimental study. Journal of Neurosurgical Science, 63(6), 714-722. http://doi.org/10.23736/S0390-5616.16.03444-5 | en_US |
dc.identifier.issn | 0390-5616 | |
dc.identifier.issn | 1827-1855 | |
dc.identifier.uri | http://doi.org/10.23736/S0390-5616.16.03444-5 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5023 | |
dc.description.abstract | BACKGROUND: Despite optimal medical therapy the mortality rate approaches 50% in MCA infarctions. Although recent studies have been showed life-saving effect of hemicraniectomy; there are a few data available in regard to neuroprotection effect of decompressive craniectomy (DC). We induced a malignant cerebral ischemia model by intraluminal permanent middle cerebral artery occlusion (MCAo) in male rats for defining the neuroprotective effects of early DC on brain-blood barrier (BBB) molecular changes, infarct size and cerebral edema. METHODS: A total of 48 male Spraque-Dawley rats were allocated to 4 groups; sham (N.=9). control (N.=9), experiment 1 (N.=15), experiment 2 (N.=15). DC was performed by creating a bone flap. after MCAo at 4 and 24 hours. After 28 hours of survival, all animals were sacrificed. Infarction volumes were calculated from TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-stained brain sections. In all groups, cerebral edema was quantified as a change in the percentage of brain water content. Western Blot was used to analyze the expression of tight junction protein claudin-5 and occludin. RESULTS: Brain water content was calculated 75.18 +/- 0.75% in the early DC group and 77.76 +/- 0.71% in the late DC group. No significant difference was found between experiment groups (P=0.178). In the early DC group; occludin and claudin-5 were significantly expressed at higher levels compared to late DC group (occluding, P=0.013; claudin-5. P=0.034). At early DC group (73.38 +/- 23.11 mm(3)) the final infarct volumes were significantly smaller than in the late DC group (377.18 +/- 39.23 mm(3)) (P=0.013). CONCLUSIONS: The study results supported the neuroprotective effects of early DC in malignant MCA infarcts. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Edizioni Minerva Medica | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Reperfusion | en_US |
dc.subject | Rat | en_US |
dc.subject | Occlusion | en_US |
dc.subject | Tight Junction | en_US |
dc.subject | Focal Ischemia | en_US |
dc.subject | Hemispheric Stroke | en_US |
dc.subject | Pathological Evaluation | en_US |
dc.subject | Decompressive Craniectomy | en_US |
dc.subject | Acute Ischemic-Stroke | en_US |
dc.subject | Blood-Brain-Barrier | en_US |
dc.title | Neuroprotective effects of hemicraniectomy in malignant middle cerebral artery infarctions: Experimental study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Neurosurgical Science | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 63 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 714 | en_US |
dc.identifier.endpage | 722 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.23736/S0390-5616.16.03444-5 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q2 | en_US |