Kurum Yazarı "Cansız, Derya" WoS İndeksli Yayınlar Koleksiyonu İçin Listeleme
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3-Pyridinylboronic acid ameliorates rotenone-induced oxidative stress through Nrf2 target genes in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Karagöz, Atakan; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Springer, 2022)Parkinson's disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone is a neurotoxin that can pass the blood-brain barrier and is ... -
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study
Sürmen, Mustafa Gani; Sürmen, Saime; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Büyükkayhan, Derya; Emekli Alturfan, Ebru (Wiley, 2022)Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), is the principal fatty acid of medium-chain triglycerides in ketogenic diets. Beneficial effects of ketogenic ... -
Bisphenol a reveals its obesogenic effects through disrupting glucose tolerance, oxidant–antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish
Beler, Merih; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Dandin, Esra; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (SAGE Publications Ltd, 2022)Obesogens affect lipid metabolism, and genetic or epigenetic factors may also contribute to the progression of obesity. Endocrine-disrupting chemicals (EDCs) are the most striking among obesogens. Bisphenol A (BPA) is an ... -
Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos
Kaplan, Gül; Beler, Merih; Ünal, İsmail; Karagöz, Atakan; Eğilmezer, Gizem; Üstündağ, Ünsal Veli; Cansız, Derya; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (2024)Exposure of zebrafish embryos to glucose is a suitable model for the fetal hyperglycemia seen in gestational diabetes. Diethylhexyl phthalate (DEHP), which is considered an endocrine-disrupting chemical, is one of the most ... -
The effect of acetic acid-induced pain in Parkinson's disease model in zebrafish
Cansız, Derya; Ünal, İsmail; Beler, Merih; Üstündağ, Ünsal Veli; Ak, Esin; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Elsevier B.V., 2023)Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, ... -
Endotoxin of porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs
Gündüz, Gizem; Beler, Merih; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru; Köse, Kemal Naci (Springer, 2023)Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontal diseases, is also associated with hyperglycemia-associated systemic diseases, including diabetes mellitus (DM). Gingipains are the most important ... -
Identification of molecular network of gut-brain axis associated with neuroprotective effects of PPAR delta-ligand erucic acid in rotenone-induced Parkinson's disease model in zebrafish
Ünal, İsmail; Cansız, Derya; Sürmen, Mustafa Gani; Sürmen, Saime; Sezer, Zehra; Beler, Merih; Üstündağ, Ünsal Veli; Güzel, Elif; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Wiley, 2023)Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, the neuroprotective potential of different PPAR delta-agonists has been shown. We aimed to reveal the ... -
Morphine ameliorates pentylenetetrazole-induced locomotor pattern in zebrafish embryos; mechanism involving regulation of opioid receptors, suppression of oxidative stress, and inflammation in epileptogenesis
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Alturfan, Ahmet Ata; Tiber, Pınar Mega; Emekli Alturfan, Ebru (Taylor and Francis Ltd., 2023)Zebrafish (Danio rerio) is becoming an increasingly important model in epilepsy research. Pentylenetetrazole (PTZ) is a convulsant agent that induces epileptic seizure-like state in zebrafish and zebrafish embryos and is ... -
Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos
Karagöz, Atakan; Beler, Merih; Altun, Büşra Dilara; Ünal, İsmail; Cansız, Derya; Gündüz, Hüseyin; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru; Erçalık Yalçınkaya, Şebnem (Elsevier Masson s.r.l., 2023)Panoramic x-ray units are widely used in dental radiodiagnostics. Patients are exposed to relatively low radiation doses with panoramic imaging, but considering lifetime frequency of exposure, even a small risk can have ... -
Sodium-dependent glucose co-transporter-2 inhibitor empagliflozin exerts neuroprotective effects in rotenone-induced Parkinson's disease model in zebrafish; mechanism involving ketogenesis and autophagy
Ünal, İsmail; Cansız, Derya; Beler, Merih; Sezer, Zehra; Güzel, Elif; Emekli Alturfan, Ebru (Elsevier B.V., 2023)Sodium-dependent glucose co-transporter-2 (SGLT2) inhibitor empagliflozin (EMP), is the new class of oral hypoglycemic agent approved as a treatment for Type 2 diabetes. SGLT2 inhibitors may induce ketogenesis through ... -
Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation
Dandin, Esra; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Beler, Merih; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (Elsevier Ltd, 2022)Obesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have ...