Bölüm "İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı" WoS İndeksli Yayınlar Koleksiyonu için listeleme
Toplam kayıt 76, listelenen: 61-76
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The relationship of elevated hepatic fibrosis-4 index score with pneumonia severity index and in hospital mortality among COVID-19 patients admitted to intensive care unit
(Yerküre Tanıtım ve Yayıncılık A.Ş., 2022)Objective: We investigated the relationship hepatic fibrosis-4 (FIB-4) index score calculated in the early period and pneumonia severity index (PSI) and in-hospital mortality in patients hospitalized in the intensive care ... -
Short-term diet restriction but not alternate day fasting prevents cisplatin-induced nephrotoxicity in mice
(MDPI AG, 2020)Cisplatin (CP) is one of the most preferred platinum-containing antineoplastic drugs. However, even in nontoxic plasma concentrations, it may cause kidney injury. To be able to increase its effective pharmacological dose, ... -
Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses
(Academic Press Inc., 2024)Social isolation is associated with poor stroke outcome, but the underlying molecular mechanisms were largely unknown. In male Balb/C mice exposed to transient middle cerebral artery occlusion (MCAo), we examined the effects ... -
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia
(Pergamon Elsevier Science Ltd, 2018)Sirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
(Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ... -
A study of the effects of metformin, a biguanide derivative, on annulus fibrosus and nucleus pulposus cells
(Turkish Neurosurgical Society, 2020)AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues.MATERIAL ... -
The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline
(Wiley, 2017)Oxidative stress had a great importance in development of complications in diabetes. We investigated effects of melatonin and pentoxifylline in diabetic mice. Swiss albino mice (n=40) were divided into four groups: ... -
Systematic evaluation of desmopressin administered to patients with aneurysmal subarachnoid hemorrhage in the light of the literature
(Turkish Neurosurgical Society, 2020)AIM: To discuss the management of patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) developing after subarachnoid hemorrhage, in a comparative manner in the light of the literature.MATERIAL ... -
Systematic evaluation of promising clinical trials-gene silencing for the treatment of glioblastoma
(Turkish Neurosurgical Society, 2019)AIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field ... -
Toxicity of the acetyl-para-aminophenol group of medicines to intact intervertebral disc tissue cells
(Spandidos Publications Ltd., 2021)The present study aimed to investigate the effects of paracetamol, an analgesic and antipyretic that is used in emergency departments and neurosurgery departments for postoperative pain management on intervertebral disc ... -
TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice
(Elsevier Inc., 2023)Cryptochromes (CRYs), transcriptional repressors of the circadian clock in mammals, inhibit cAMP production when glucagon activates G-protein coupled receptors. Therefore, molecules that modulate CRYs have the potential ... -
The unconventional growth factors cerebral dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor promote post-ischemic neurological recovery, perilesional brain remodeling, and lesion-remote axonal plasticity
(Springer, 2023)Considerable efforts are currently made to develop strategies that boost endogenous recovery once a stroke has occurred. Owing to their restorative properties, neurotrophic factors are attractive candidates that capitalize ... -
Utilization of biotechnological drugs in rare diseases requiring the use of off-label drugs in children in Turkey
(TÜBİTAK Scientific and Technological Research Council of Turkey, 2021)Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards off label drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. ... -
Utilization trend of gastric acid-suppressing agents in relation to analgesics
(Wiley, 2022)Background: Controversies exist about excessive use of gastric acid-suppressing agents or lack of adequate indications, especially when co-prescribed with analgesics for gastroprotection. We aimed to analyze the nationwide ... -
What are realistic expectations to become free of overactive bladder symptoms? Experience from non-interventional studies with propiverine
(Springer, 2022)Plain Language Summary Unmet expectations are a major reason why patients with overactive bladder syndrome discontinue treatment. To enable evidence-based counselling of patients on realistic expectations, we have determined ...