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Toplam kayıt 10, listelenen: 1-10
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
(Taylor & Francis Ltd, 2022)
Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ...
Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish
(SAGE Publications Ltd, 2020)
Cancer continues to be a major cause of mortality globally. Zebrafish present suitable models for studying the mechanisms of genotoxic carcinogens. The aim of this study was to investigate the interaction between ...
Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation
(Elsevier Ltd, 2022)
Obesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have ...
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish
(Springer, 2021)
Background Dysfunction of the gastrointestinal tract (GIT) is one of the most common non-motor symptom of Parkinson's Disease (PD). Pathological processes causing PD were suggested to initiate in the enteric nervous system ...
Quantitative phosphoproteomics to resolve the cellular responses to octanoic acid in rotenone exposed zebrafish
(Wiley, 2021)
Ketosis is a potentially beneficial metabolic state for health especially in neurological conditions including Parkinson's disease (PD). Medium-chain-triglycerides (MCT) have specific metabolic properties and they are ...
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study
(Wiley, 2022)
Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), is the principal fatty acid of medium-chain triglycerides in ketogenic diets. Beneficial effects of ketogenic ...
Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish
(Taylor and Francis Ltd, 2020)
Aim: The aim of this study is to investigate the possible protective effects of mitoquinone and oleandrin on rotenone induced Parkinson’s disease in zebrafish. Materials and methods: Adult zebrafish were exposed to rotenone ...
Identification of molecular network of gut-brain axis associated with neuroprotective effects of PPAR delta-ligand erucic acid in rotenone-induced Parkinson's disease model in zebrafish
(Wiley, 2023)
Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, the neuroprotective potential of different PPAR delta-agonists has been shown. We aimed to reveal the ...
Endotoxin of porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs
(Springer, 2023)
Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontal diseases, is also associated with hyperglycemia-associated systemic diseases, including diabetes mellitus (DM). Gingipains are the most important ...
The effect of acetic acid-induced pain in Parkinson's disease model in zebrafish
(Elsevier B.V., 2023)
Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, ...