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Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
(Nature Publishing Group, 2019)
The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ...
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival
(Academic Press Inc Elsevier Science, 2019)
Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ...
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
(Czech Medical Soc, 2019)
Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ...
Role of erythropoietin and its receptor in the development of endometriosis in rats
(Galenos Yayıncılık, 2019)
Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial ...
The therapeutic role of minocycline in Parkinson's disease
(Bioexcel Publishing LTD, 2019)
Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline ...