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Toplam kayıt 135, listelenen: 61-70
Potential criteria for frameworks to support the evaluation of innovative medicines in upper middle-income countries-A systematic literature review on value frameworks and multi-criteria decision analyses
(Frontiers Media SA, 2020)
Background Multicriteria Decision Analysis (MCDA), a formal decision support framework, has been growing in popularity recently in the field of health care. MCDA can support pricing and reimbursement decisions on the macro ...
Ghrelin action on GnRH neurons and pituitary gonadotropes might be mediated by GnIH-GPR147 system
(Walter De Gruyter Gmbh, 2016)
Acylated ghrelin (AG) effect on GnRH secretion is mediated, at least in part, by GH secreta-gogue receptor (GHS-R) which is present in the GnRH neurons. As the acylation is mandatory for binding to GHS-R, unacylated isoform ...
Systematic review and meta-analysis of tocilizumab therapy versus standard of care in over 15,000 COVID-19 pneumonia patients during the first eight months of the pandemic
(MDPI, 2021)
Background. Tocilizumab is an anti-IL-6 therapy widely adopted in the management of the so-called "cytokine storm" related to SARS-CoV-2 virus infection, but its effectiveness, use in relation to concomitant corticosteroid ...
Polycystic ovary syndrome: A disorder of reproductive age, its pathogenesis, and a discussion on the emerging role of herbal remedies
(Frontiers Media SA, 2022)
Polycystic ovary syndrome (PCOS) is a very common, complex, and heterogeneous endocrine disorder of women that involves a combination of environmental and genetic factors. PCOS affects women of growing age particularly at ...
The brain protective effect of rtms (repetitive transcranial magnetic stimulation) in depression: A mini-review in animal studies
(Bentham Science Publishers, 2016)
There are rapidly replicating human data suggesting the therapeutic and neurorestorative role of repetitive transcranial magnetic stimulation (rTMS) in clinical depression. However there are only limited experimental studies ...
B cells and progressive multifocal leukoencephalopathy: Search for the missing link
(Frontiers Media, 2015)
Progressive multifocal leukoencephalopathy (PML) is a deadly demyelinating disease due to JC virus (JCV) replication in the brain. PML classically occurs in patients with severe immunodepression, and cases have recently ...
An integrated framework for non-traditional machining process technology selection in healthcare applications
(Strojarski Facultet, 2022)
In spite of continuous progress in technical advancement, the conventional machining process became unsatisfactory in the healthcare field due to its disadvantages. This inadequacy lead researchers to consider using the ...
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
(MDPI, 2019)
G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...
Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: Current status and uses
(MDPI, 2016)
Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, ...
Cellular protection and therapeutic potential of tocotrienols
(Bentham Science Publishers Ltd., 2011)
Tocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to ...