Ara
Toplam kayıt 20, listelenen: 11-20
Effects of gallic acid on endometrial cancer cells in two and three dimensional cell culture models
(Asian Pacific Organization for Cancer Prevention, 2021)
Background and Aim: Cell culture studies are an indispensable tools used to understand basic physiological, biophysical and biomolecular mechanisms. Although traditional two-dimensional (2D) cell culture models are more ...
Novel benzimidazole derivatives: Cytotoxic and apoptotic properties on lung cancer cell line
(Bentham Science Publishers, 2020)
Background: Benzimidazole derivatives are privileged molecules known to have a wide variety of biological activities. In medicinal chemistry, due to the ring's structural similarity to nucleotides, its derivatives were ...
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
(Frontiers Media S.A., 2022)
Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ...
3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos
(Taylor & Francis Ltd, 2022)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the molecular pathways in the pathogenesis of ...
Expression of pro-apoptotic and anti-apoptotic proteins in granulosa cells of women with diminished ovarian reserve
(Springer, 2022)
Purpose To evaluate the expressions of caspase-3 and cytochrome c and heat shock protein 70 (Hsp70) in granulosa cells (GCs) from women with normal ovarian reserve (NOR) and diminished ovarian reserve (DOR) undergoing ...
Laurocerasus officinalis Roem. fruit extract induces cell death through caspase mediated apoptosis in gastric cancer cell lines
(Walter de Gruyter GmbH, 2021)
Objectives: Laurocerasus officinalis Roem. fruits are traditionally used for several health problems. Although there are some studies about its antiproliferative effects on different cancer cells, no study was reported ...
Can the imbalance between neurotrophic and apoptotic proteins be the "beware the ides of march" for unaffected relatives of schizophrenia patients?
(Springer, 2022)
Schizophrenia (SZ) is a mental disorder with a strong genetic basis as well as epigenetic aspects. Siblings of patients with SZ can share certain endophenotypes with the patients, suggesting that siblings may be important ...
The role of TNF-α and its target HSP-70 in triggering apoptosis in normozoospermic and non-normozoospermic samples
(NLM (Medline), 2022)
Objective: Semen analysis is performed as one of the screening tests for infertility, including motility, morphology, and concentration observation. We aimed to investigate the expression rates of tumor necrosis factor-α ...
Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos
(Elsevier Masson s.r.l., 2023)
Panoramic x-ray units are widely used in dental radiodiagnostics. Patients are exposed to relatively low radiation doses with panoramic imaging, but considering lifetime frequency of exposure, even a small risk can have ...
LDH-A inhibitor as a remedy to potentiate the anticancer effect of docetaxel in prostate cancer
(Ivyspring International Publisher, 2024)
Increased LDH-A activity promotes tumor growth, migration, invasion, and metastasis. This study aimed to investigate the effects of the combination of LDH-A inhibitor and Docetaxel on apoptosis and epithelial-mesenchymal ...