ORCID "0000-0003-4228-4577" Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed için listeleme
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Als2 silencing affects the expression of two NF-κB targeted genes via uxt in adult mouse primary spinal motor neuron culture
Çetin Ozansoy, Muzaffer Beyza; Ozansoy, Mehmet (Logos Medical Publishing, 2018)Aim: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons. Als2 is one of the genes that cause ALS, and its mutations leads to loss of function in alsin protein. The interaction between ... -
Changes in als2 expression leads to different outcomes on the expression of two NF-kB targeted genes in N2a and C2C12 cell lines
Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza (Logos Medical Publishing, 2019)Objective: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting spinal and cortical motor neurons. Motor neuron degeneration leads to progressive muscular atrophy. Als2 (alsin) is one of the causative ... -
The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy
Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ... -
Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza; Yuluğ, Burak; Çankaya, Şeyda; Kılıç, Ertuğrul; Göktekin, Şule; Kılıç, Ülkan (Elsevier Science Ltd., 2020)Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its ... -
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
Yuluğ, Burak; Ozansoy, Mehmet; Alökten, Merve; Çetin Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Hanoğlu, Lütfü; Kılıç, Ülkan; Kılıç, Ertuğrul (2020)Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ... -
Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Altıntaş, Mehmet Özgen; Ozansoy, Muzaffer Beyza; Günay, Necmeddin; Kılıç, Ertuğrul; Kılıç, Ülkan (Scientific and Technological Research Council of Turkey (TÜBİTAK), 2020)Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, ...