Browsing Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed by ORCID "0000-0003-3616-1204"
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A(2A) adenosine receptors regulate multiple organ failure after hemorrhagic shock in mice
Keleştemur, Taha; Németh, Zoltán H.; Pacher, Pal; Antonioli, Luca; Haskó, György (Lippincott Williams and Wilkins, 2022)Trauma hemorrhagic shock (T/HS) is a clinical condition that causes multiple organ failure that needs rapid intervention. Restricted oxygen at the cellular level causes inflammation and subsequent cell death. Adenosine ... -
Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling
Keleştemur, Taha; Németh, Zoltán H.; Pacher, Pal; Beesley, Jennet; Robson, Simon C.; Eltzschig, Holger K.; Haskó, György (NLM (Medline), 2023)BACKGROUND: Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of ... -
Effects of neurotrophic factors cdnf and manf on brain plasticity and repair after brain ischemia
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Altunay, Serdar; Dalay, Arman; Dilden, Aysun; Sertel, Elif; Keleştemur, Taha; Yalçın, Esra; Kılıç, Ülkan; Saarma, Mart; Kılıç, Ertuğrul (Wiley-Blackwell, 2016)... -
Effects of normobaric oxygen and melatonin on reperfusion injury: Role of cerebral microcirculation
Beker, Mustafa; Çağlayan, Ahmet Burak; Keleştemur, Taha; Çaǧlayan, Berrak; Yalçın, Esra; Yuluǧ, Burak; Kılıç, Ülkan; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Impact Journals, 2015)In order to protect the brain before an irreversible injury occurs, penumbral oxygenation is the primary goal of current acute ischemic stroke treatment. However, hyperoxia treatment remains controversial due to the risk ... -
Efficacy of one-hour negative pressure wound therapy and magnetic field energy in wound healing
Özer, Aysel Yıldız; Keskin, İlknur; Keleştemur, Taha; Aytürk, Nilüfer; Ersavaş, Cenk; Günal, Mehmet Yalçın (MA Healthcare Ltd, 2024)Objective: Wound healing is an important aspect of health but needs further research to identify the effects and interactions of different treatment approaches on healing. The aims of this study were to investigate the ... -
Evaluation of components of the extracellular purinergic signaling system in human sepsis
Lovászi, Marianna; Németh, Zoltán H.; Keleştemur, Taha; Sánchez, Itzel V.; Antonioli, Luca; Pacher, Pál; Wagener, Gebhard; Haskó, György (2024)Objective: Extracellular purines such as adenosine triphosphate (ATP), uridine triphosphate (UTP), and uridine diphosphate (UDP) and the ATP degradation product adenosine are biologically active signaling molecules, which ... -
Evaluation of components of the extracellular purinergic signaling system in human sepsis
Lovászi, Marianna; Németh, Zoltán H.; Keleştemur, Taha; Sánchez, Itzel V.; Antonioli, Luca; Pacher, Pál; Wagener, Gebhard; Haskó, György (2024)Objective: Extracellular purines such as adenosine triphosphate (ATP), uridine triphosphate (UTP), and uridine diphosphate (UDP) and the ATP degradation product adenosine are biologically active signaling molecules, which ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Evidence that osteogenic and neurogenic differentiation capability of epidural adipose tissue-derived stem cells was more pronounced than in subcutaneous cells
Solmaz, Bilgehan; Şahin, Ali; Keleştemur, Taha; Kılıç, Ertuğrul; Kaptanoğlu, Erkan (Tübitak Scientific & Technical Research Council Turkey, 2020)Background/aim: The management of dura-related complications, such as the repairment of dural tears and reconstruction of large dural defects, remain the most challenging subjects of neurosurgery. Numerous surgical techniques ... -
HMG-CoA reductase inhibition promotes neurological recovery, peri-lesional tissue remodeling, and contralesional pyramidal tract plasticity after focal cerebral ischemia
Kılıç, Ertuğrul; Reitmeir, Raluca; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kelestemur, Taha; Ethemoğlu, Muhsine Sinem; Öztürk, Gürkan; Hermann, Dirk M. (Frontiers Research Foundation, 2014)3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis, and ... -
Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
Beker, Mustafa Çağlar; Çağlayan, Berrak; Çağlayan, Ahmet Burak; Kelestemur, Taha; Yalçın, Esra; Çağlayan, Aysun; Kılıç, Ülkan; Baykal, Ahmet Tarık; Reiter, Russel J.; Kılıç, Ertuğrul (Nature Publishing Group, 2019)The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ...