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dc.contributor.authorCeylan, Bahadır
dc.contributor.authorArslan, Ferhat
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorFincancı, Muzaffer
dc.contributor.authorYardımcı, Cem
dc.contributor.authorFersan, Esra
dc.contributor.authorPaşaoğlu, Esra
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorMert, Ali
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:18:47Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:18:47Z
dc.date.issued2016en_US
dc.identifier.citationCeylan, B., Arslan, F., Batırel, A., Fincancı, M., Yardımcı, C., Fersan, E. ... Mert, A. (2016). Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir. Turkish Journal of Gastroenterology, 27(1), 42-46. https://dx.doi.org/10.5152/tjg.2015.150348en_US
dc.identifier.issn1300-4948
dc.identifier.urihttps://hdl.handle.net/20.500.12511/482
dc.identifier.urihttps://dx.doi.org/10.5152/tjg.2015.150348en_US
dc.description.abstractBackground/Aims: We aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on viral kinetics and virologic response to tenofovir and entecavir treatment in patients with chronic hepatitis B virus (HBV) infection.Materials and Methods: This study was designed as a retrospective multicenter cohort study. The impact of hepatosteatosis on pre-treatment serum HBV DNA levels and also on the virologic response to either tenofovir or entecavir at 6 and 12 months of therapy was investigated. Results: A total of 145 cases were involved in the study [median age 40 (18-73) years, 90 (62%) males]. In multivariate analysis, it was detected that patients with NAFLD were older and had a higher body mass index (BMI) [Odds ratio (95% confidence interval) and p-value for age were 1.040 (1.003-1.079) and 0.033 and for BMI were 1.348 (1.190-1.528) and 0.0001, respectively]. When only the 43 patients who were younger than 35.5 years old and who had a BMI less than 27.59 were investigated, serum high-density lipoprotein (HDL) levels and serum HBV DNA levels were lower in patients with NAFLD in multivariate analysis [Odds ratio (95% confidence interval) and p-values for serum HDL level and HBV DNA level were 0.864 (0.061-0.980) and 0.023 and 0.995 (0.990-0.999) and 0.025, respectively]. Totally, 57 and 75 of the patients had received entecavir and tenofovir, respectively. Conclusion: Viral replication decreases in patients with chronic HBV infection in the presence of NAFLD, and NAFLD had no impact on the virologic response to entecavir and tenofovir treatmenten_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEntecaviren_US
dc.subjectFatty Liveren_US
dc.subjectHepatitis B Virusen_US
dc.titleImpact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecaviren_US
dc.typearticleen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-9658-7560en_US
dc.authorid0000-0001-8554-7651en_US
dc.authorid0000-0001-8022-7325en_US
dc.authorid0000-0001-8945-2385en_US
dc.identifier.volume27en_US
dc.identifier.issue1en_US
dc.identifier.startpage42en_US
dc.identifier.endpage46en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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