dc.contributor.author | Ceylan, Bahadır | |
dc.contributor.author | Arslan, Ferhat | |
dc.contributor.author | Batırel, Ayşe | |
dc.contributor.author | Fincancı, Muzaffer | |
dc.contributor.author | Yardımcı, Cem | |
dc.contributor.author | Fersan, Esra | |
dc.contributor.author | Paşaoğlu, Esra | |
dc.contributor.author | Yılmaz, Mesut | |
dc.contributor.author | Mert, Ali | |
dc.date.accessioned | 08.07.201910:49:13 | |
dc.date.accessioned | 2019-07-08T20:18:47Z | |
dc.date.available | 08.07.201910:49:13 | |
dc.date.available | 2019-07-08T20:18:47Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Ceylan, B., Arslan, F., Batırel, A., Fincancı, M., Yardımcı, C., Fersan, E. ... Mert, A. (2016). Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir. Turkish Journal of Gastroenterology, 27(1), 42-46. https://dx.doi.org/10.5152/tjg.2015.150348 | en_US |
dc.identifier.issn | 1300-4948 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/482 | |
dc.identifier.uri | https://dx.doi.org/10.5152/tjg.2015.150348 | en_US |
dc.description.abstract | Background/Aims: We aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on viral kinetics and virologic response to tenofovir and entecavir treatment in patients with chronic hepatitis B virus (HBV) infection.Materials and Methods: This study was designed as a retrospective multicenter cohort study. The impact of hepatosteatosis on pre-treatment serum HBV DNA levels and also on the virologic response to either tenofovir or entecavir at 6 and 12 months of therapy was investigated. Results: A total of 145 cases were involved in the study [median age 40 (18-73) years, 90 (62%) males]. In multivariate analysis, it was detected that patients with NAFLD were older and had a higher body mass index (BMI) [Odds ratio (95% confidence interval) and p-value for age were 1.040 (1.003-1.079) and 0.033 and for BMI were 1.348 (1.190-1.528) and 0.0001, respectively]. When only the 43 patients who were younger than 35.5 years old and who had a BMI less than 27.59 were investigated, serum high-density lipoprotein (HDL) levels and serum HBV DNA levels were lower in patients with NAFLD in multivariate analysis [Odds ratio (95% confidence interval) and p-values for serum HDL level and HBV DNA level were 0.864 (0.061-0.980) and 0.023 and 0.995 (0.990-0.999) and 0.025, respectively]. Totally, 57 and 75 of the patients had received entecavir and tenofovir, respectively. Conclusion: Viral replication decreases in patients with chronic HBV infection in the presence of NAFLD, and NAFLD had no impact on the virologic response to entecavir and tenofovir treatment | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Entecavir | en_US |
dc.subject | Fatty Liver | en_US |
dc.subject | Hepatitis B Virus | en_US |
dc.title | Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Turkish Journal of Gastroenterology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-9658-7560 | en_US |
dc.authorid | 0000-0001-8554-7651 | en_US |
dc.authorid | 0000-0001-8022-7325 | en_US |
dc.authorid | 0000-0001-8945-2385 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 42 | en_US |
dc.identifier.endpage | 46 | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |