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dc.contributor.authorAydınlı, Fatmagül İlayda
dc.contributor.authorÇelik, Eşref
dc.contributor.authorKurt Vatandaşlar, Burcu
dc.contributor.authorKerman, Bilal Ersen
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:18:47Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:18:47Z
dc.date.issued2016en_US
dc.identifier.citationAydınlı, F. İ., Çelik, E., Kurt Vatandaşlar, B. ve Kerman, B. E. (2016). Myelin disorders and stem cells: As therapies and models. Turkish Journal of Biology, 40(5), 1068-1080. https://dx.doi.org/10.3906/biy-1512-83en_US
dc.identifier.issn1300-0152
dc.identifier.urihttps://hdl.handle.net/20.500.12511/479
dc.identifier.urihttps://dx.doi.org/10.3906/biy-1512-83
dc.description.abstractMyelin disorders burden millions of people around the world, yet existing therapies are inadequate to cure them. Current remedies commonly treat the symptoms with minimal to no effect on the actual cause of the disorder. The basis and/or the mechanism of demyelination is not known for many of the disorders either. In recent years, stem cells of variable origin have been used in clinical trials as transplant agents to restore the defective biochemical process or the damaged tissue. We summarize the outcomes of these trials for demyelination disorders. The capability of reprograming mature cells into stem cells equips researchers with a new tool to replicate disease phenotypes in cell culture dishes for basic research and therapeutic screens. The applications of in vitro myelination disorder models are also discussed. The combined outcome of the discussed studies offers a promising future as stem cell transplantation generally results in decreased symptoms and improved quality of life. However, the mechanism of action of the interventions is not known and in cases of negative outcomes the reasons are usually obscure. Further basic science studies along with clinical interventions should close the knowledge gap and should help spread the positive results to a larger population.en_US
dc.language.isoengen_US
dc.publisherTubitak Scientific & Technical Research Councilen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStem Cellsen_US
dc.subjectInduced Pluripotent Stem Cellsen_US
dc.subjectMyelinen_US
dc.subjectPelizaeus–Merzbacher Diseaseen_US
dc.subjectAdrenoleukodystrophyen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectSubacute Sclerosing Panencephalitisen_US
dc.titleMyelin disorders and stem cells: As therapies and modelsen_US
dc.typereviewen_US
dc.relation.journalTurkish Journal of Biologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-1106-3288en_US
dc.identifier.volume40en_US
dc.identifier.issue5en_US
dc.identifier.startpage1068en_US
dc.identifier.endpage1080en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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