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dc.contributor.authorYükseloğlu, Emel Hülya
dc.contributor.authorOrtuğ, Alpen
dc.contributor.authorRayimoğlu, Gülten
dc.contributor.authorYonar, Fatma Çavuş
dc.contributor.authorErkan, Itır
dc.contributor.authorKara, Umut
dc.contributor.authorİşlek, Dilek Salkım
dc.contributor.authorKolusayın Ozar, Melek Özlem
dc.contributor.authorDastan, Kadir
dc.contributor.authorKarataş, Ömer
dc.identifier.citationYükseloğlu, E. H., Ortuğ, A., Rayimoğlu, G., Yonar, F. Ç., Erkan, I., Kara, U. ... Karataş, Ö. (2019). Association of 10 single nucleotide polymorphism loci with nicotine addiction in the Anatolian population? Biotechnology and Biotechnological Equipment, 33(1), 1011-1017.
dc.description.abstractThe study aimed to discover some variables influencing the risk of nicotine dependence in the Anatolian population. We examined 10 candidate genes and analysed 10 single nucleotide polymorphism (SNP) loci in 50 cases and 50 controls in a preliminary study. The main purpose of this work was to provide predicative definition in this regard. Buccal swab samples were collected from 50 cases and 50 controls, who had volunteered to participate in the study. The Fagerström Test for Nicotine Dependence (FTND) score of 4 or more was required for the case group. The control group was strictly chosen from people who had an FTND score of 0. SNP loci were genotyped and variations were observed in five SNP loci (rs16969968, rs806380, rs3733829, rs6474412, rs1329650). Based on these results, polymorphism was identified in the Turkish population in five SNP loci (rs16969968, rs806380, rs6474412, rs37333829, rs1329650). Although our findings indicated a non-significant association between the 10 selected loci and nicotine dependence in the Anatolian population, we believe that with a larger number of cases with five SNP loci, the variance we find will provide significant results for both forensic geneticists and psychiatrists. Since, to our knowledge, this is the first work to explore the potential association of these SNPs with nicotine addiction in the Anatolian population, the results should be expanded with larger sample groups.en_US
dc.description.sponsorshipIstanbul University - Cerrahpasa Scientific Research Projects Uniten_US
dc.publisherTaylor and Francis Ltd.en_US
dc.rightsAttribution 4.0 International*
dc.subjectDrug Dependenceen_US
dc.subjectForensic Psychiatryen_US
dc.subjectNicotine Addictionen_US
dc.titleAssociation of 10 single nucleotide polymorphism loci with nicotine addiction in the Anatolian population?en_US
dc.relation.journalBiotechnology and Biotechnological Equipmenten_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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